Trabajos de Titulación - Medicina

URI permanente para esta colección

Examinar

Envíos recientes

Mostrando 1 - 5 de 2271
  • Ítem
    Acceso Abierto
    Relación entre COVID-19 con el desarrollo de enfermedades autoinmunes
    (Universidad Católica de Cuenca., 2024) Ortega Castro, Jennifer Johanna; Hugo Merino, Gabriel Aníbal; 0106316987
    Currently, there are a large number of people diagnosed with SARS-CoV-2, drawing attention to the appearance of some diseases of autoimmune origin after exposure to this infection. Their association is believed to be due to mechanisms that include molecular mimicry, autoantibodies, and stimulation of inflammatory signaling. The objective of this narrative review is to identify the relationship of COVID-19 with the development of autoimmune diseases. After reviewing updated information, it is concluded that the main mechanisms involved in the development of autoimmunity after SARS-CoV-2 infection includes molecular mimicry, the presence of autoantibodies, and the cytokine storm typical of the COVID-19 disease. The autoimmune diseases with which a direct relationship was established: Guillan-Barré syndrome, autoimmune encephalitis, Graves' disease, Hashimoto's thyroiditis, autoimmune thrombocytopenic purpura and vasculitis, however, more studies are required to support this relationship
  • Ítem
    Embargo
    Proyecto de titulación embargado con fines de de publicación de impacto
    (Universidad Católica de Cuenca., 2024) Córdova Vivar, María Angélica; Flores Flores, Pedro Martín; 0104864657
  • Ítem
    Embargo
    Principales escalas predictoras de mortalidad asociadas a shock séptico de origen abdominal en adultos
    (Universidad Católica de Cuenca., 2023) Verdesoto Herrera, Fernanda Elizabeth; Yánez Castro, Jorge Luis; 1900606052
    Background: sepsis is defined as a condition that causes organ dysfunction, the abdominal type is the second most frequent cause of admission to the intensive care unit, especially in countries with economic decline. Aim: to describe the efficiency of the main scales predicting mortality in the evaluation of septic shock of abdominal origin in adults. Method: literature review using Scopus, Pubmed and Cochrane databases. Results: the research describes the efficacy of mortality predictor scales through 8 articles, mainly Sequential Organ Failure Assessment and Acute Physiology Assessment System and Chronic Health Assessment over others described in adult patients with septic shock of abdominal origin, demonstrating a great benefit of their use on mortality prediction. Conclusions: the scales that predict mortality with the greatest predictive value include APACHE II and SOFA, although other systems such as SAPS II, MEWS, NEWS are also very significant with respect to prediction, and this will depend on the patient’s situation and comorbidities. The need for a scale that includes gastrointestinal criteria to facilitate the diagnosis and timely approach to septic shock of abdominal origin, including gastrointestinal signs and symptoms, will be more effective in predicting mortality.
  • Ítem
    Acceso Abierto
    Leucemia de células peludas en paciente geriátrico. Reporte de caso y revisión de la literatura
    (Universidad Católica de Cuenca., 2023) Morocho Tapia, Diego Andrés; Puente Mosquera, Karola Adriana; 0107540858
    process that evolves to B cells. It is a rare entity that manifests in the last decades of life with a peak incidence between 60 and 70 years. The etiology is currently uncertain however 90% of cases derive from a BRAF V600E mutation. The course of the disease is indolent, so the patient is usually asymptomatic; however, when the symptoms are present, symptoms B, pancytopenia and splenomegaly stand out. The diagnosis is made through a correct history, blood count, bone marrow biopsy, flow cytometry and a CT scan that helps us identify the progression of the disease. Purine analogues such as Cladribine are the first-line treatment, achieving complete remission in 90% of cases. An important point to highlight is the difficult access in our country due to its cost and availability. monoclonal studies can be used together when the disease is refractory to conventional treatment. The objective of this report is to present the case of a patient with hairy cell leukemia, and demonstrate the importance of a quick and accurate diagnosis, to treat effectively and prevent this disease from becoming a growing health problem. A clinical case of a 71-year-old male patient with weight loss, splenomegaly accompanied by leukopenia and thrombocytopenia is presented, receiving purine analogues as the first choice, reaching complete remission. The objective of this report is to present the case of a patient with hairy cell leukemia, and demonstrate the importance of a quick and accurate diagnosis, to treat effectively and prevent this disease from becoming a growing health problem
  • Ítem
    Embargo
    Papel del estrés oxidativo y opciones terapéuticas en infección por SARS COV-2
    (Universidad Católica de Cuenca., 2023) Quilambaqui Brito, Ivan Ronaldo; Muñoz Palomeque, Danilo Gustavo; 1400972998
    Introduction: elevated levels of oxidative stress in patients with SARS-CoV-2 infection generate tissue damage, causing organ dysfunction and generating a suitable environment for viral replication. Aim: to describe the mechanisms by which oxidative stress is generated in patients with Sars-Cov-2 and its therapeutic options. Methodology: a non-experimental and narrative study of bibliographic review type was carried out, data will be collected from original articles in indexed journals using the PubMed database. Results: patients with SARS-CoV-2 infection present elevated levels of oxidative stress, on the contrary, the levels of antioxidant agents are depleted, increasing the degree of oxidative stress to a greater extent. The use of N-acetylcysteine in a COVID-19 positive patient is a subject under discussion since, although there are inconsistencies in its degree of efficacy, no adverse effects of any kind have been observed. Conclusions: there are antioxidant therapeutic options under study, however, despite having a high safety profile, their efficacy in the treatment of COVID-19 is still unproven.