En este servicio en línea podrá consultar los trabajos académicos y de investigación
producidos en los diferentes campus de la Universidad Católica de Cuenca, en formato
digital: tesis, monografías, libros, artículos, etc.
Envíos recientes
Participación activa de estudiantes de Medicina de pregrado en las rotaciones clínicas. Revisión bibliográfica
(Universidad Católica de Cuenca., 2025) Castro Madero , Nathalie Margarita; Cárdenas Heredia, Freddy Rosendo; 0106957376
Medical education significantly influences the development of competencies and knowledge consolidation. These are conducted in the Teaching Support Departments to assess students and provide them with increasingly complex tasks as they interact with patients. This research aims to describe the development of undergraduate medical students' active participation in the teaching-learning process during clinical rotations. A literature review was developed based on scientific articles from online databases such as Scopus, PubMed, and Web of Science. An analysis was also conducted using a matrix to select information. It was evidenced that assisted practices improve the students' academic performance, create more self-confidence by repeating the procedures, and promote their professionalism. The tutorials provided by the teacher reinforce their individual knowledge by centering on the student's mistakes, which improve their skills through practice. Higher education institutions must establish new pedagogical models and roles for teaching support departments, tutors, and students to guarantee quality health care and forster academic excellence and professionalism. Medical education requires an in-depth analysis of the strengths and weaknesses of the participants to improve health services.
Lupus eritematoso inducido por fármacos asociado a inhibidores de puntos de control inmunitario
(Universidad Católica de Cuenca., 2025) Erraez Ramón, Marlon Damián; Esqueda Jiménez , Aleifel Antonio; 0104754015
Introduction: Drug-induced lupus erythematosus is an autoimmune condition. Its severity can vary and mainly affects women, with a pathogenesis that includes hyperactive immune response and genetic, hormonal, and environmental factors.
Objective: To demonstrate the association between drug-induced lupus erythematosus and immune checkpoint inhibitors (ICIs).
Methodology: A narrative literature review was conducted, analyzing studies from PubMed, Science Direct, and Scopus on the relationship between drug-induced lupus using medications that act as ICIs, focusing on relevant indexed publications and using MESH terminology.
Results: Research reveals that medications acting by inhibiting immune checkpoint points, such as pembrolizumab, can reactivate or exacerbate drug-induced lupus erythematosus, with adverse effects ranging from skin reactions to severe complications.
Conclusions: The relationship between drug-induced lupus erythematosus and ICIs is complex, offering therapeutic benefits and risks, especially in patients with autoimmune predisposition. The need for a personalized approach and rigorous monitoring is emphasized to improve patient treatment and quality of life.
Avances en la investigación de xenotrasplantes. Revisión Sistemática
(Universidad Católica de Cuenca., 2025) Gonzalez Lituma, Gabriel Fernando; Crespo Argudo , Karla Marcela; 0302565353
Introduction: Xenotransplantation involves the transplantation of genetically modified animal cells, tissues, or organs into human recipients. The increase in human life expectancy has led to a growing number of patients with chronic diseases and end-stage organ failure. Although transplantation remains the most effective treatment, there is a significant imbalance between organ supply and demand. As a potential solution, xenotransplantation has emerged as a promising alternative. Objective: To examine recent advances in xenotransplantation research. Methodology: A systematic review was conducted in accordance with the PRISMA 2020 guidelines, using literature from the last five years retrieved from the PubMed and ScienceDirect databases.
Results: Ten high-impact studies were included, focusing on post-transplant survival, the use of immunosuppressive therapy, genetic modification of donor species, and immune rejection in clinical trials.
Conclusions: The review reveals promising advances, particularly in improving the survival of porcine renal xenografts. These advances are attributed to enhanced immunosuppressive therapies and genetic engineering, which improve compatibility. However, challenges remain. Although genetic modifications in humanized pigs show potential, recipient survival remains limited. The heterogeneity of studies underscores the need for well-structured future research to significantly advance this emerging medical field.
Keywords: xenotransplantation, immunological barrier, kidney transplantation, genetic engineering, public health
Proyecto de Titulación embargado con fines de publicación de impacto.
(Universidad Católica de Cuenca, 2025) Cantos Albán, Juan Edison; Chica Villacis , Carlos Eduardo; 0302086053
“Análisis comparativo Ecuador-Argentina sobre la eficiencia del derecho penal en la protección de la propiedad intelectual: propuesta de reforma al artículo 208A del COIP”
(Universidad Católica de Cuenca, 2025) Morocho Cabrera, Mabel Stefanya; Chica Villacis, Carlos Eduardo; 0150487924
This study examines the criminal protection of intellectual property in Ecuador, specifically through Article 208A of the Comprehensive Organic Criminal Code (COIP, by its Spanish acronym). It draws a comparison with Argentine legislation to identify shortcomings in Ecuadorian regulations, such as a lack of precision in key concepts and difficulties in prosecuting these offenses criminally. Using a comparative analysis, the research examines Argentina's legal framework, its sanctions, and complementary approaches. It enabled the development of a proposed reform for Article 208A of the COIP, primarily focused on clarifying the concept of “commercial scale," strengthening the proportionality of penalties, and enhancing criminal prosecution through specialized mechanisms. The study concludes that this reform would enable a more effective and equitable application of the law, distinguishing between occasional infringers and organized criminal structures. Moreover, it emphasizes the importance of enhancing the training of justice operators and fostering international cooperation. The main contribution of this study is to offer a concrete proposal to optimize Ecuadorian intellectual property regulation, fostering a balance between intellectual property protection and legal certainty
