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Item type: Ítem , Access status: Acceso Abierto , Riesgo cardiovascular en mujeres que utilizan drospirenona/estetrol vs levonorgestrel/etinilestradiol: revisión sistemática(Universidad Católica de Cuenca., 2026) Castro Vera, Jorge Luis; Espinoza Romero, Mishell AbigailBackground: Combined hormonal contraceptives have been associated with cardiovascular events such as venous thromboembolism, hypertension, myocardial infarction, and stroke. Differences in the hormonal composition between drospirenone/estetrol (E4/DRSP) and levonorgestrel/ethinyl estradiol (EE/LNG) may influence the cardiovascular safety profile of users. Objective: To assess cardiovascular risk in women using E4/DRSP compared with EE/LNG through a systematic review of clinical studies. Methods: A systematic review was conducted in PubMed, ScienceDirect, and SciELO, including randomized clinical trials and observational studies published in English and Spanish. Methodological quality was assessed using the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale. Secondary studies, those with insufficient data, or those involving irrelevant populations were excluded. The findings were synthesized through a narrative analysis. Results: Twenty-three studies were included. E4/DRSP showed a lower cardiovascular impact compared with EE/LNG, with an average incidence of venous thromboembolism of 3.66 cases per 10,000 woman-years versus 6–8 cases for EE/LNG. In addition, E4/DRSP was associated with a safer profile in women with preexisting risk factors, such as obesity and hypertension, and had a lower impact on hemostatic and metabolic parameters. Keywords: cardiovascular risk, drospirenone/estetrol, levonorgestrel/ethinyl estradiol, hormonal contraceptives, venous thromboembolismItem type: Ítem , Access status: Acceso Abierto , Proyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2026) Maldonado Duque, Darwin Joshua; Silva Rojas, Mario StefanoItem type: Ítem , Access status: Acceso Abierto , TRABAJO DE TITULACIÓN EMBARGADO CON FINES DE PUBLICACION(Universidad Católica de Cuenca., 2026) Narváez Espinoza, Mayerly Fernanda...Item type: Ítem , Access status: Acceso Abierto , Diseño de espacios inmersivos para descanso en el Museo Pumapungo(Universidad Católica de Cuenca., 2026) Torres Padilla, Joselyn LissethThis research addresses the issue of the lack of adequate resting spaces at the Pumapungo Museum, which currently do not meet optimal criteria for ergonomics, environmental comfort, or visitor interaction strategies. This situation limits the user experience along the museographic tour and reduces the potential of the museum as a space for staying and learning. The study is conducted through applied research, utilizing a mixed-methods approach with a descriptive-propositive scope, formally grounded in the design project method. A spatial, lighting, thermal, acoustic, and aesthetic diagnosis of the selected areas was conducted using direct observation techniques, technical recording sheets, and environmental measurements. This allowed for the identification of deficiencies related to the absence of ergonomic furniture, poor technological integration, and a lack of visual identity linked to the museum’s cultural narrative. As a result, an interior design proposal is presented based on the implementation of interactive resting spaces that integrate anthropometrically supported furniture, immersive projection systems, ambient lighting, and multisensory resources. The proposal aims to enhance the visitor experience, strengthen their connection with cultural heritage, and position the Pumapungo Museum as a benchmark in museographic innovation through immersive interior design and its technical and economic feasibility.Item type: Ítem , Access status: Acceso Abierto , Seguridad y tolerabilidad del nusinersen y onasemnogene como tratamientos para la atrofia muscular espinal: revisión sistemática(Universidad Católica de Cuenca., 2026) Fernandez Taday, Angela Fernanda; Suquinagua Ortiz, Jhon FernandoIntroduction: Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by a deletion in exon 7 of the SMN1 gene on chromosome 5q13. This alteration leads to a reduction in SMN protein, which is essential for the function of motor neurons. The most affected age group is children, who present clinical features such as asthenia, atrophy, paralysis, and, in severe cases, respiratory failure. For this reason, it is essential to analyze the safety and tolerability of therapies such as nusinersen and onasemnogene in treating this disease. Objective: To compare the safety and tolerability between nusinersen and onasemnogene as treatments for spinal muscular atrophy. Methodology: A systematic review was conducted through searches in databases such as Scopus, PubMed, and ProQuest, using inclusion and exclusion criteria, keywords based on health descriptors, and Boolean operators such as "AND" and "OR." The results will be presented in tables following the PRISMA method, and the methodological quality will be analyzed using the Newcastle-Ottawa Scale. Results: A total of 105 publications were found, of which 18 in English were selected, including clinical trials, systematic reviews, and retrospective observational studies. Conclusions: According to the collected data, nusinersen is safer than onasemnogene, with side effects managed according to each patient's symptomatology. Specifically, tolerability with onasemnogene is greater in patients (infants) with SMA type 1 and in patients with SMA type 2 and 3 (preschoolers and adults) treated with nusinersen.
