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Item type: Ítem , Access status: Embargo , Rabdomiosarcoma embrionario en adulto joven: reporte de caso(Universidad Católica de Cuenca., 2026) Aray Coellar , Irma RosalíaProyecto de Titulación embargado para publicación. Estará disponible a la fecha de publicación o de cierre de embargoItem type: Ítem , Access status: Acceso Abierto , Necrólisis epidérmica tóxica: Reporte de caso(Universidad Católica de Cuenca., 2026) Sarmiento Amón , Santiago JosuéIntroduction: This case report describes a severe presentation of toxic epidermal necrolysis (TEN) in a 27-year-old female patient, triggered by the use of lamotrigine. TEN is a rare and potentially life-threatening immunological reaction that affects the skin and mucous membranes. This clinical case highlights the importance of recognizing early symptoms and prompt management to improve the prognosis. Clinical manifestations: The patient presented with erythematous lesions that evolved into painful blisters and extensive skin desquamation, as well as ocular involvement with a foreign-body sensation, oral and genital mucosal involvement, and respiratory symptoms requiring intensive care. Diagnosis: The diagnosis was confirmed based on medication history, clinical presentation, and evaluation with the SCORTEN scale, which estimated a mortality of 35.5%. Treatment: Discontinuation of the causative agent, management of complications, and administration of glucocorticoids and intravenous immunoglobulins were included, which progressively improved the skin lesions in conjunction with multidisciplinary management, achieving stabilization of respiratory and hemodynamic function. The patient was discharged after 9 days of hospitalization. This case highlights the need for timely diagnosis and management to prevent severe complications of TEN, emphasizing the effectiveness of the combination of glucocorticoids and immunoglobulins. Conclusion: Early identification of TEN and rapid initiation of immunomodulatory treatment can reduce complications and improve clinical outcomes in severe cases.Item type: Ítem , Access status: Acceso Abierto , Proyecto de Titulación embargado con fines de publicación de impacto.(Universidad Católica de Cuenca., 2026) Apodaca Vera, Juan ManuelItem type: Ítem , Access status: Embargo , Mieloma múltiple no secretor: Reporte de caso(Universidad Católica de Cuenca., 2026) Vásquez Astudillo, Renata FabiolaProyecto de Titulación embargado para publicación. Estará disponible a la fecha de publicación o de cierre de embargoItem type: Ítem , Access status: Acceso Abierto , “Análisis econométrico de las ventas del sector manufacturero ecuatoriano en el contexto del boom de importaciones bajo el régimen 4x4 (2017-2025)”(Universidad Católica de Cuenca., 2026) Yanangomez Duchi, Luis GustavoIn recent years, e-commerce and the use of the courier regime have significantly transformed import dynamics in Ecuador. This study analyzes the impact of these changes on sales performance in the manufacturing sector compared to the agricultural sector during the period 2017–2025. Utilizing administrative data from the Internal Revenue Service (SRI, by its acronym in Spanish) and a quantitative approach based on panel data models and a difference-in-differences model with fixed effects, the relative effects on sales are estimated using annual and semi-annual specifications. The results show that, prior to 2020, there were no significant differences between manufacturing and agricultural sales. However, starting in 2020, a persistent decline in the sales differential of the manufacturing sector is observed, intensifying from 2022 onward, when this differential was reduced by approximately 25% compared to the base period (2017). This gap worsened in 2023, with the decline reaching around 43%. Nevertheless, a partial recovery is observed in 2024 and 2025; however, the sales differential remains below the level observed in the base period. The semi-annual analysis shows a pattern consistent with these results, while the placebo test using the construction sector does not show a similar pattern, reinforcing the robustness of the results and suggesting that the observed losses in manufacturing respond to sector-specific factors affecting manufacturing.
