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Item type: Ítem , Access status: Embargo , Proyecto de Titulación embargado para publicación. Estará disponible a la fecha de publicación o de cierre de embargo(Universidad Católica de Cuenca, 2026) Criollo Nivelo, Sandra VerónicaItem type: Ítem , Access status: Acceso Abierto , Desarrollo de recursos tridimensionales para una guía interactiva orientada al aprendizaje guiado del entorno de Unity(Universidad Católica de Cuenca., 2026) José Alberto , Guillen ParraLow Poly three-dimensional modeling is a graphic representation technique aimed at optimizing geometry through the controlled use of polygons, enabling the development of stylized and efficient visual assets for real-time interactive environments without compromising the established aesthetic coherence. This project focuses on the creation of three-dimensional assets in Blender for the development of an interactive guide implemented in Unity. The process involves low-poly modeling of the playable character, interactive objects, and decorative elements, followed by UV mapping, the application of color maps, and the configuration of reusable materials to optimize graphic resources. For the character, a rigging system is implemented using an armature and weight painting, enabling controlled deformations and the creation of basic animations. The resulting assets are subsequently integrated into Unity through prefabs, materials, colliders, and an Animator Controller to manage interactions and animation states. Additionally, there is a graphic design proposal for a guidebook, considering criteria such as composition, visual hierarchy, spatial distribution, and color consistency. The development follows the waterfall methodology, sequentially structuring the planning, design, production, integration, and validation phases, resulting in a functional, coherent, and visually consistent interactive guide. The application's performance is analyzed with Unity Profiler, evaluating its behavior during operation. Additionally, a Likert scale is applied to assess the modeling, artistic style, color selection, readability, and thematic coherence, thereby determining the technical and visual feasibility of the developed proposal.Item type: Ítem , Access status: Acceso Abierto , Eficacia del plasma rico en plaquetas en múltiples dosis versus monodosis en el tratamiento de la gonartrosis: Revisión sistemática(Universidad Católica de Cuenca., 2026) Amaguaya Amaguaya, Ingrid Dalay; Duchitanga Torres , Sebastián AlejandroTitle: Efficacy of Multiple-Dose Versus Single-Dose Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis. A Systematic Review. Objectives: To evaluate the efficacy of platelet-rich plasma (PRP) administered in multiple doses versus a single dose in reducing pain, improving joint function, and enhancing quality of life in patients with knee osteoarthritis. Methodology: We included randomized clinical trials and observational studies (2019–2024) in English involving patients with knee osteoarthritis (Kellgren-Lawrence grades I–IV) that compared single-dose or multiple-dose PRP with other intra-articular interventions or with each other. We excluded systematic reviews, animal studies, and studies with incomplete data. Studies were retrieved from PubMed, Scopus, and Taylor & Francis, with searches conducted through February 15, 2025. Risk of bias was assessed using GRADEpro, classifying studies as high, moderate, or low risk. Results were summarized in descriptive tables, comparing changes in VAS and WOMAC scores at 6 weeks and 3, 6, and 12 months. Results: Six articles (4 randomized clinical trials, 2 prospective studies) involving 392 patients were included. Multiple doses of PRP significantly reduced pain (VAS) and improved function (WOMAC) at 12 months compared with a single dose, particularly in patients with mild-to-moderate knee osteoarthritis. Discussion: Limitations included heterogeneity in PRP preparation and bias among patients. Multiple doses yielded better results in the early stages. Conclusion: Multiple doses of PRP are more effective at reducing pain, improving function, and enhancing quality of life in patients with knee osteoarthritis. A regimen of three injections is recommended.Item type: Ítem , Access status: Acceso Abierto , Desarrollo de un prototipo de videojuego tipo metroidvania en principios cognitivo-conductuales para la representación de conflictos psicosociales(Universidad Católica de Cuenca., 2026) Mieles Serrano , Jorge AndrésThis study presents the development of a two-dimensional metroidvania video game prototype whose purpose is to integrate principles of Cognitive Behavioral Therapy into the design of the narrative, game mechanics, and levels to represent human characteristics without entering the clinical field, promoting players’ personal reflection on these characteristics. The proposal arises from the need to explore new ways of taking advantage of the expressive potential of video games by incorporating psychological principles into the interactive experience. An iterative development methodology was implemented in Unity, together with the Mechanics, Dynamics, and Aesthetics (MDA) framework as a guide for the design, with the support of a professional psychologist to ensure the appropriate conceptualization and adaptation of psychological principles into boss mechanics, traps, and environments. The video game incorporates exploration, combat, and environmental storytelling, structured around thematic areas and bosses that represent human characteristics such as anger and manipulation. It was validated through playtesting sessions and user experience evaluation to analyze the consistency between the implemented mechanics, the narrative, and players' perceptions. It is concluded that video games can contribute to the interactive representation of psychological concepts and encourage personal reflection.Item type: Ítem , Access status: Acceso Abierto , Terapia electroconvulsiva en comparación con la Estimulación Magnética Transcraneal en episodios depresivos post COVID-19. Revisión sistemática(Universidad Católica de Cuenca., 2026) Andrade Chimbo, Diana Kasandra; Calero Ortiz , Steeven AnthonyIntroduction: COVID-19 left numerous sequelae, significantly affecting people's quality of life. Among these consequences, depression is of particular concern, with uncertainty regarding its neurobiological impact. Therefore, therapies such as Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation (TMS) have emerged as potentially viable treatment options. General Objective: To evaluate the efficacy of Electroconvulsive Therapy and Transcranial Magnetic Stimulation in the treatment of post-COVID-19 depressive episodes. Methodology: A systematic review was conducted based on the criteria established by the PRISMA 2020 statement, including articles published in Spanish and English, with free access, and involving individuals aged ≥18 years. Reviews, meta-analyses, and gray literature that did not address ECT and/or TMS for post-COVID-19 depression were excluded. Searches were conducted in the PubMed, Taylor & Francis, and Scopus databases from November 2024 to March 2025, using the JBI tool. Results: Case reports and cross-sectional studies highlighted the efficacy of TMS, associated with high tolerability, in moderate cases, whereas ECT showed greater efficacy in severe cases. Good adherence to the procedures was identified, with minor adverse effects. Discussion: The results supported the use of these therapies on an individualized basis; however, limitations such as methodological heterogeneity and small sample sizes increased the risk of bias. Conclusions: TMS is recommended for moderate cases and ECT for severe cases; however, further controlled studies are needed to strengthen the evidence supporting this practice.
