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Item type: Ítem , Access status: Acceso Abierto , Alteraciones metabólicas en etnia Shuar 2018-2019(Universidad Católica de Cuenca., 2026) Noboa Rodas , Samantha Anais; Serrano Andrade , Alfredo MatiasIntroduction: Metabolic syndrome (MS) is a highly prevalent pathology that encompasses metabolic disorders such as central obesity, hypertension, dyslipidemia, and insulin resistance, all of which increase the risk of cardiovascular and metabolic diseases. What is striking is the presence of this condition in ethnic groups such as the Shuar population. Methodology: A cross-sectional, descriptive, observational approach was used to evaluate 300 Shuar individuals in Morona Santiago, Ecuador. Data were collected through sociodemographic questionnaires, anthropometric measurements, and biochemical tests, ensuring strict compliance with ethical and privacy principles. Results: A total of 10.67% of the participants were diagnosed with MS, with a higher prevalence found in women and individuals over 55 years of age. The results indicate high rates of fasting glucose, reduced HDL, and prevalence of abdominal obesity, indicating an increased risk of cardiometabolic complications. Conclusions: Research reveals that dietary changes and an increase in sedentary lifestyles may be deteriorating the health of the Shuar community. It is imperative to develop and implement public health policies that recognize the cultural and social needs of indigenous communities in order to reduce the impact of MS.Item type: Ítem , Access status: Acceso Abierto , Comparación de polimorfismos genéticos e interferón tipo 1 en la predicción de susceptibilidad del lupus eritematoso sistémico: Revisión sistemática(Universidad Católica de Cuenca., 2026) Astudillo Rodríguez , María Eduarda; Rodas Arias , María AuxiliadoraIntroduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with multiple clinical manifestations, which makes early diagnosis difficult. These delays can adversely affect patients' quality of life and pose an additional problem for the healthcare system. Currently, the roles of genetic polymorphisms and type I interferon are being investigated as possible biomarkers to assess predisposition to systemic lupus erythematosus and facilitate earlier and more personalized diagnoses. Objective: To compare the utility of genetic polymorphisms and type I interferon levels as predictors of susceptibility to systemic lupus erythematosus, based on available scientific evidence. Methodology: A systematic review will be carried out using databases such as PubMed, Scopus, Cochrane, and Taylor & Francis. Original studies, performed in humans, published in English or Spanish between 2019 and 2024, will be considered. Narrative reviews, letters to the editor, and analyses with significant methodological limitations or small samples will be excluded. Results: Genetic polymorphisms and variations in type I interferon levels are expected to be important markers for the early detection of SLE and may be useful in personalized healthcare settings. Discussion: Variations such as rs2205960 (TNFSF4), as well as changes in genes such as FOXP3 and IFIH1, have been linked to an increased risk of SLE. However, genetic diversity among populations highlights the need to validate these findings in different population contexts.Item type: Ítem , Access status: Acceso Abierto , Factores psicosociales vinculados a conductas alimentarias de riesgo en adolescentes.(Universidad Católica de Cuenca., 2026) Coronel Cárdenas, Karen MaríaIntroduction. Disordered eating behaviors are practices aimed at reducing body weight; they predominate at an early age, specifically during adolescence, impairing the individual’s quality of life as they are characteristic of eating disorders, whose core symptomatology is shared, sometimes being implicit, such as concern about weight, and other times explicit, such as binge eating. In this context, prompt detection of these behaviors is recommended to prevent future consequences. Objective. This study aimed to analyze the psychosocial factors associated with risky eating behaviors in adolescents. Methodology. A literature review was conducted using a qualitative-descriptive approach, in which scientific literature was consulted in databases such as ScienceDirect, PubMed, Scopus, SciELO, Springer Nature Link, and Taylor & Francis. The selected studies addressed the research question posed. Results. The evidence from the reviewed literature agreed that the most common risky eating behaviors reported in the selected sample were food restriction and binge eating episodes. Regarding psychosocial variables, the main factors were problematic use of social media, body image dissatisfaction, and the presence of body-shaming comments. Conclusions. The development of disordered eating behaviors during adolescence is closely linked to psychological factors and the sociocultural environment. The results highlighted the importance of addressing this issue from a comprehensive perspective.Item type: Ítem , Access status: Embargo , Proyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2026) Campoverde Navarrete, Ana CristinaItem type: Ítem , Access status: Acceso Abierto , Dihidroartemisinina/Piperaquina versus Artemisinina como tratamiento de malaria por Plasmodium Falciparum resistente a la cloroquina: una revisión sistemática(Universidad Católica de Cuenca., 2026) Picón Nivelo, Dorian Paul; Mendoza Zambrano , MelissaDihydroartemisinin/piperaquine versus artemisinin as treatment for malaria by Plasmodium falciparum resistant to chloroquine: a systematic review. Objective: Evaluate the efficacy of dihydroartemisinin/piperaquine compared to monotherapy with artemisinin in the treatment of malaria caused by Plasmodium falciparum resistant to chloroquine. Methodology: Studies published in the last decade, in English or Spanish, with complete text available, were included. They were considered clinical trials, observational studies, and case series. Systematic reviews, meta-analyses, studies in animals, and incomplete or duplicated articles were excluded. Systematic searches were carried out in the databases of Scopus and PubMed, finishing in 2024. The tool GradePro was applied to value the level of confidence in the evidence and the possibility of bias. The data were organized through descriptive tables, analyzing efficacy, prevalence of resistance, and time of parasitic elimination. Results: A total of 18 articles were selected, including more than 10,000 patients. In the majority, DHA/PPQ (Dihydroartemisinin/Piperaquine) showed rates of cure superior to 95%, a faster elimination of the parasite (less than 48 hours), and a minor recurrence compared to artemisinin alone. Discussion: The limitations included risk of bias in some observational studies and imprecision in specific molecular data. Without embargo, the global evidence supports the superiority of DHA/PPQ in efficacy and control of resistance. Conclusion: It is more effective than monotherapy and must be prioritized in zones with resistance to chloroquine. Its use, sustained together with the molecular vigilance, is key to preserving the antimalarial efficacy.
