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Item type: Ítem , Access status: Acceso Abierto , Sertralina versus trimebutina en el tratamiento del Síndrome de intestino irritable: una revisión sistemática(Universidad Católica de Cuenca., 2026) Cumbicus Castillo, Roxana Carolina; Pineda Morocho , Micaela Angely“SERTRALINE VERSUS TRIMEBUTINE IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME: A SYSTEMATIC REVIEW” Objective: This systematic review aimed to compare the efficacy of sertraline versus trimebutine in the treatment of irritable bowel syndrome (IBS), considering both digestive symptoms and the presence of emotional comorbidities. Methodology: Open-access articles published in Spanish or English within the last decade, that included an adult population aged 18 years or older, were selected. Clinical trials and observational studies were considered, excluding reviews and case reports. The databases Scopus, PubMed, Taylor & Francis, Cochrane, ProQuest, Web of Science, and Springer Nature were used in a search period from November 2024 to April 2025. The risk of bias was assessed using the RoB 2 tool for clinical studies and the JBI Critical Appraisal Tools for observational studies and narrative reviews. The results were synthesized descriptively using tables and figures. Results: Nine articles were analyzed. Trimebutine demonstrated moderate efficacy in alleviating digestive symptoms, particularly when combined with other treatments. In contrast, sertraline offered better results in patients with IBS associated with anxiety or depression, although a possible increased risk of microscopic colitis was observed. Discussion: The identified limitations include methodological heterogeneity and limited access to certain studies. Conclusions: Trimebutine is adequate in mild cases of IBS, while sertraline is preferable when there is emotional involvement. The importance of personalizing treatments and promoting higher-quality research is emphasized.Item type: Ítem , Access status: Acceso Abierto , Apoyo social percibido y depresión en mujeres con cáncer de mama. Una revisión bibliográfica.(Universidad Católica de Cuenca., 2026) Arias Neira, Samantha BrigitteBreast cancer is one of the leading causes of death among women worldwide and has significant psychological repercussions, including depression, which affects the patients’ well-being and quality of life. In this context, perceived social support has been recognized as a relevant factor in coping with the disease. Objective: To describe the correlation between perceived social support and depression in women with breast cancer through a literature review. Methodology: A literature review was conducted in the Scopus, Web of Science, PubMed, and Taylor & Francis databases. The descriptors breast cancer, perceived social support, and depression were used, including 30 studies published between 2013 and 2026 that met the established selection criteria. Development: The evidence analyzed showed an inverse correlation between perceived social support and depression. Women who reported greater support from family, friends, and significant others exhibited fewer depressive symptoms, better emotional adjustment, greater coping ability, and a better quality of life during oncologic treatment. Conclusion: Perceived social support is a protective factor against depression in women with breast cancer. In particular, family and emotional support are associated with lower levels of depressive symptoms and better adaptation to the disease. Therefore, strengthening support networks and integrating them into comprehensive care can significantly contribute to the psychological well-being and quality of life of this population.Item type: Ítem , Access status: Embargo , Proyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2026) Barros Chávez, Ángel GiovannyItem type: Ítem , Access status: Acceso Abierto , Utilidad de leuprolide en comparación con implantes de histrelina en el tratamiento de la pubertad precoz central: Revisión sistemática(Universidad Católica de Cuenca., 2026) Tanguila Morales , Alan Jhosue; Torres Espinoza , Mayerly JuliethIntroduction: Central precocious puberty (CPP) is an early activation of the hypothalamic-pituitary-gonadal axis, manifesting before the age of 8 years in girls and 9 years in boys. It is classified as idiopathic or organic, and treatment is based on GnRH analogues such as leuprolide and histrelin implants, whose effectiveness and safety profile are compared in this review. Objective: To evaluate the clinical efficacy of leuprolide versus histrelin implants in the treatment of CPP, considering adherence, tolerability, and adverse events. Methodology: Articles and comparative studies in English or Spanish published within the last 5 years, which were performed on humans over 18 years of age, were selected. Cases, reviews, and studies lacking methodological rigor were excluded. The sources of information were PubMed and Taylor & Francis. The risk of bias was evaluated using the RoB 2 (clinical trials) and JBI (observational) tools. The results, including adverse events and adherence, were tabulated, along with a narrative on efficacy. Results: Nineteen studies were included: 2 clinical trials, 5 cross-sectional, and 12 cohort studies. Both treatments showed effective suppression of the gonadotropic axis. Histrelin showed a longer duration of action and fewer adverse effects. Leuprolide showed good adherence, although it requires frequent administration. Discussion: Limitations include the risk of bias in some studies and heterogeneity in populations and therapeutic regimens; however, both treatments demonstrated high efficacy and safety. Conclusions: Both leuprolide and histrelin are valid options for CPP; the choice should be based on the patient's profile, access, and family preferences.Item type: Ítem , Access status: Embargo , Proyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2026) Chamba Lara, Jhosselin Adelaida
