Trabajos de Titulación - Medicina

URI permanente para esta colección

Examinar

Envíos recientes

Mostrando 1 - 5 de 2278
  • Ítem
    Acceso Abierto
    Los alimentos transgénicos como disruptores endocrinos
    (Universidad Católica de Cuenca., 2024) Brabo Abril, Romel Dario; Vanegas Izquierdo, Patricia Elizabeth; 0106395825; 9BT2024-MTI038
    Introduction: Genetically modified foods have been the subject of debate and concern due to their potential impact on human health and the environment. One of the less understood aspects of this controversy is their possible role as hormonal disruptors, substances that can interfere with the endocrine system and have harmful effects on health. Objective: This research aims to characterize genetically modified foods as endocrine disruptors, exploring their properties and mechanisms of action that could affect the human endocrine system. Methodology: An exhaustive literature review of scientific investigations and publications on genetically modified foods and their potential as endocrine disruptors was conducted. Studies addressing specific properties of transgenic foods and their possible mechanisms of disruptive action on the endocrine system were selected. Results: The literature review revealed significant evidence suggesting that specific components in genetically modified foods may have endocrine-disrupting properties. Studies highlighting the impact on reproductive health, thyroid function, obesity, and other aspects of human health were identified. Conclusions: Genetically modified foods may act as endocrine disruptors, raising concerns about their effects on human health. Further research is essential to understand the underlying mechanisms better and assess the safety of genetically modified foods regarding exposure to endocrine disruptors. Additionally, effective regulations and public awareness are also necessary to address this issue comprehensively.
  • Ítem
    Acceso Abierto
    Uso de glifozinas y finerenona en pacientes con diabetes mellitus tipo 2 portadores de enfermedad renal crónica
    (Universidad Católica de Cuenca., 2024) Maldonado Castillo, Pedro Nicolàs; Bueno Castro, Andrés Santiago; 0105828123; Bueno Castro, Andrés Santiago
    Chronic kidney disease (CKD) and diabetes mellitus (DM) as co-existing diseases have grown proportionally in prevalence and, therefore, need to be highlighted as a priority global health concern due to their associated increased risk of mortality. DM is one of the main causes of CKD, affecting approximately 40% of adults diagnosed with this pathology. DM is characterized by chronic hyperglycaemia, which can lead to vascular complications, including diabetic nephropathy, and can progress to end-stage renal disease, so adequate glycemic control is significant, as well as a comprehensive management in preventing and treating these patients. Finerenone is presented as a new drug approved for treating CKD with albuminuria linked to type 2 DM, highlighting its mechanism of action and pharmacological differences with other medications, besides the benefits of sodium-glucose cotransporter 2 (iSGLT2) inhibitors in managing type 2 DM and their impact on preventing progression of CKD. The importance of a comprehensive and multidisciplinary approach in managing patients with DM and CKD is also addressed, as well as the need for future research to examine the efficacy of combining therapy with Finerenone and iSGLT2 in CKD.
  • Ítem
    Acceso Abierto
    Estado nutricional en pacientes geriátricos a través del Mini Nutritional Assessment en el Hogar Cristo Rey. Cuenca. 2023
    (Universidad Católica de Cuenca., 2024) Chacho Ullauri, Erika Gabriela; Peña Cordero, Susana Janeth; 0107942138
    Antecedents: Malnutrition is caused by a lack of intake or assimilation of nutrients, which causes body-level alteration and affects physical and mental functions. Objective: To assess the nutritional status of geriatric patients through the Mini Nutritional Assessment in the “Hogar Cristo Rey” center in the city of Cuenca in the period 2022 and 2023. Methodology: The design of the study is observational, descriptive, and cross-sectional. It was conducted on 115 geriatric patients in the “Hogar Cristo Rey” center in Cuenca, province of Azuay. The research was developed in the period 2022-2023. The sample was census-based. The data were collected by a validated Mini Nutritional Assessment (MNA) survey. The study was carried out in two phases. In the first part, sociodemographic data and associated diseases were collected. In the second phase, nutritional status was evaluated by applying the test, and anthropometric measurements such as weight, upper arm, and calf circumference were also taken. The data were processed in the SPPS database. Results: In the sociodemographic variables, most of the population are women with 59.1%, the predominant age is 75-90 years with 62.6%, 56.5% are widowed, 60% of older adults are at risk of malnutrition, and 14.8% are malnourished. The concomitant diseases most frequently found in the study population were arterial hypertension, hypothyroidism, and diabetes mellitus. Conclusions and Relevance: In this study, the nutritional status of institutionalized geriatric patients was evaluated through the Mini Nutritional Assessment, demonstrating a high risk of malnutrition in this population
  • Ítem
    Acceso Abierto
    Mola Hidatiforme Completa en Mujer Premenopáusica: Revisión Bibliográfica
    (Universidad Católica de Cuenca., 2024) Orellana Sánchez, Cinthya Verónica; Cárdenas Heredia, Freddy Rosendo; 0104209754
    Hydatidiform mole is a pathological condition caused by the abnormal growth of trophoblastic cells, which occurs most frequently in middle-aged women, resulting from a defective fusion between sperm and egg, leading to excessive growth of trophoblastic tissue. This study aimed to collect scientific literature on the hydatidiform mole, focusing on its prevalence in premenopausal women. The review used health science databases, including ScienceDirect, Scopus, PubMed, Taylor & Francis, and SciELO. The health science descriptors keywords (DeSC "Pregnancy," "Epidemiology," "Hydatidiform Mole," and "Premenopause," and MeSH terms "Epidemiology," "Hydatidiform Mole," “Pregnancy,” and "Premenopause") were used combined with Boolean operators OR, AND, NOT. The information was summarized, and narrative data analysis was applied. Nineteen scientific articles in English and Spanish were reviewed, revealing a prevalence of 1 in 1000 pregnant women over 35 years of age. Advanced maternal age is considered a significant risk factor for this condition, with a notable genetic component. The premenopausal stage, typically between the ages of 30 to 40, is a crucial factor for this condition. The most common treatment is uterine curettage
  • Ítem
    Acceso Abierto
    Ablación por radiofrecuencia como tratamiento de miomas uterinos
    (Universidad Católica de Cuenca., 2024) Mingo Paucar, Evelyn Carolina; Durán Vega, Oswaldo Jair; 0105086466
    Uterine fibroids are the most common benign solid pelvic tumor in women and represent a significant social and health burden, affecting mainly during the reproductive age. Women with fibroids report symptoms that interfere with activities of daily living. Although there are several options for the management of this pathology, hysterectomy remains the definitive treatment; therefore, there is a growing demand for less invasive therapies that preserve the uterus and improve the quality of life, thus focusing the interest of this research on radiofrequency ablation (RFA) as a therapeutic alternative for fibroids, covering the benefits, complications and the role of this procedure in fertility. Seven studies were carefully analyzed under inclusion and exclusion criteria for development. The results demonstrate that RFA is a safe and effective procedure that significantly reduces symptoms, improves quality of life, reduces fibroid size, improves future fertility, and reduces surgical reoperation rates and adverse event