Trabajos de Titulación - Bioquímica y Farmacia
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- ÍtemEmbargoProyecto de Titulación embargado con fines de publicación de impacto.(Universidad Católica de Cuenca., 2024) Cabrera Ordoñez, Sebastián Antonio; Saltos Cedillo, Carla Paulette; Torres Segarra, Silvia Maribel; 0706710902; 0107096471; García Calle
- ÍtemEmbargoProyecto de Titulación embargado con fines de publicación de impacto.(Universidad Católica de Cuenca., 2024) Reino Abad, Ana Belén; Salinas Sánchez, Lisseth Paulina; Torres Segarra, Silvia Maribel; 0105281091; 0106715659; Anthony Alxander
- ÍtemEmbargoProyecto de Titulación embargado con fines de publicación de impacto.(Universidad Católica de Cuenca., 2024) Piedra Vega, Estefany Dayanara; Arias Durán, Andrea Cristina; Martínez León, Maritza del Rosario; 1900604701; 0106812787; García Calle
- ÍtemAcceso AbiertoDeterminación de Staphylococcus aureus en bases en barra cosméticas en la ciudad de Cuenca.(Universidad Católica de Cuenca., 2024) Mejía Agudo, Diego Ismael; Tapia Pinguil, David Enmanuel; Araujo Campoverde, María Viviana; 0105269575; 0107278467; García CalleIntroduction: Staphylococcus aureus is one of the most frequently identified agents responsible for infections associated with skin care. Cosmetic products come in a wide range and are used for different purposes, such as cleansing, protection, fragrance, and enhancing skin appearance. However, there have been instances where microbial contamination affects the quality of skin care products. Objective: This research aims to determine the presence/absence of Staphylococcus aureus in stick-type cosmetic foundations in Cuenca. Methodology: The methodology applied in this research is descriptive observational, employing a qualitative cross-sectional approach by culturing samples using Petri dishes with mannitol salt agar. Results: After analyzing all the samples, a result was obtained in which all the samples in the mannitol salt agar were negative, which makes it possible to conclude this research satisfactorily since this bacterium was not found in the cosmetic foundations in Cuenca. Conclusion: At the end of the investigation, it was concluded the absence of S. aureus in the cosmetic foundations analyzed.
- ÍtemAcceso AbiertoEvaluación de la capacidad cardiotóxica de los fitoquímicos presentes en la planta Kalanchoe Pinnata, empleando modelos QSAR(Universidad Católica de Cuenca., 2024) Matamoros Salinas, Alexander Rodrigo; Páez Vásquez, Melany Dayana; Carpio Arévalo, Juan Marcelo; 0706151321; 0105782056; García CalleIntroduction: The growing interest in the use of traditional medicine has led to research on the chemical compounds of plants with medicinal properties; in this regard, Kalanchoe pinnata has been the focus of studies due to the potential of its phytochemicals to be cardiotoxic. It is known that the extract of its leaves has been used to treat coughs, wounds, bumps, burns, fever, headaches, and others. Some chemical studies have described the presence of alkaloids, triterpenes, glycosides, flavonoids, cardenolides, steroids, and bufadienolides. Objective: In this study, plant phytochemicals that may have cardiotoxic effects were evaluated and categorized using two QSAR models, known as ADMETlab 0.2 and Pred-hERG. Methodology: For the development of this thesis a non-experimental, cross-sectional, descriptive research design was used; the research approach was quantitative. Results: A predictive analysis of the phytochemicals present in the Kalanchoe pinnata plant was conducted using QSAR models, and the probability of eight molecules to block the hERG channel was identified. Conclusion: Based on the data obtained, it was confirmed that some metabolites have cardiotoxic potential, such as bufadienolides, and some molecules that have not been previously reported in the literature are shown to be probable cardiotoxic agents.
