Trabajos de Titulación - Bioquímica y Farmacia
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- ÍtemEmbargoProyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2024) Gualpa Cox, Marcos Moises; Lopez Salazar , Juan Fernando; Arteaga Sarmiento, Sandra Denisse; 0942190398; 0105539621
- ÍtemAcceso AbiertoEvaluación del potencial cardiotóxico de los fitoquímicos de la planta Urginea marítima mediante los métodos computacionales.(Universidad Católica de Cuenca., 2024) Idrovo Hidalgo, Fausto Daniel; Lucero Arias , Pamela Katherine; Carpio Arévalo, Juan Marcelo; 0107455321; 0106983257Introduction: This research evaluated the cardiotoxic activity of phytochemicals from Urginea maritima, which is traditionally used in herbal medicine. However, the therapeutic application of these compounds requires a rigorous evaluation of their potential side effects. In the cardiovascular system, the crucial aspect to consider is the interaction of these phytochemicals with the hERG channel of the heart. Objective: To evaluate the cardiotoxicity of phytochemicas from U. maritima in humans, using Quantitative Structure Activity Relationship (QSAR) tools. Methodology: A quantitative and descriptive experimental research design was used to develop this research. A methodological approach including virtual tools such as QSAR, Pred-hERG, and ADMETlab 2.0, was used to predict the cardiotoxicity of the identified compounds. Results: It is suggested that certain phytochemicals from U. maritima, in addition to those already known, may have cardiotoxicity in humans. It was found that 23 phytochemicals act as blockers of the hERG channel in the myocardium. Among these, the top 10 with the highest reliability index were selected, with five molecules grouped in the bufadienolides group, one belonging to the glycosides, and another to the diterpenoids; for the remaining three, no literature was found that classified them. Conclusion: The need to continue contributing to the published scientific literature on these new advancements and consolidation approaches was corroborated, due to the limited information available on several of the compounds present in these medicinal plants, for which there is still no evidence on their cardiotoxicity.
- ÍtemAcceso Abierto“Estudio comparativo de la calidad biofarmacéutica de diferentes marcas comerciales de tabletas de ibuprofeno 600 mg”(Universidad Católica de Cuenca., 2024) Reino Bermeo, Kevin Santiago; Arcentales Morocho, Jorge Alfredo; Cárdenas Cordero, Janneth Fernanda; 0150090538; 0150577336ntroduction: Ibuprofen is one of the most consumed drugs in the world due to its ability to relieve pain, a common condition in many pathologies. Therefore, quality control of this drug is essential to guarantee its safety and efficacy. Objective: To conduct a comparative study of the biopharmaceutical quality of 600 mg ibuprofen tablets of various brands commercially available in the Ecuadorian market, applying physicochemical tests. Methodology: The methodology applied was experimental, cross-sectional, and prospective and was used to control the quality of 4 different commercial brandsof 600 mg ibuprofen. Results: Four ibuprofen brands were evaluated, two generic and two innovative: MK, Ferbertt, Caplin Point, and Genfar. The tablets, with a diameter of 18 to 20 mm, did not present deformations, maintained uniform color and odor, and met the Pharmacopoeia specifications in the weight test. Conclusion: All the tablets evaluated complied with the Pharmacopoeia specifications and did not present significant changes in their biopharmaceuticalquality, becoming stable formulations
- ÍtemAcceso AbiertoEstudio comparativo de las características fisicoquímicas y biofarmacéuticas de diferentes marcas comerciales de tabletas de paracetamol 500 mg(Universidad Católica de Cuenca., 2024) Guamán Espejo, Walter Lenin; Jadán Cadmilema, Miriam Alexandra; Cárdenas Cordero, Janneth Fernanda; 0105075931; 0104832092INTRODUCTION: Tablet control should be carried out during manufacturing and also at the final product, thus ensuring that it complies with the established specifications. These controls generally include physical, chemical, and biopharmaceutical characteristics, ensuring these drugs are quality, safe, and effective. OBJECTIVE: To conduct a comparative study of the physicochemical and biopharmaceutical characteristics of 500 mg paracetamol tablets through physicochemical tests in five different brands distributed in Cuenca-Ecuador. METHODOLOGY: This research work on paracetamol tablets is experimental and uses a cross-sectional approach. RESULTS: The analyzed 500 mg paracetamol tablets present uniformity in terms of their organoleptic characteristics, hardness, friability, disintegration, and weight uniformity tests. The results comply with USP 30 standards, although there was a physical parameter that could affect the friability result. CONCLUSION: The physicochemical and biopharmaceutical characteristics of the analyzed drugs are optimal since these medications previously underwent several controls and filters to be marketed nationally; however, it is essential to consider that environmental factors may influence the obtained data
- ÍtemAcceso AbiertoDeterminación de coliformes totales y fecales en fresas expendidas en supermercados y mercados de la ciudad de Cuenca(Universidad Católica de Cuenca., 2024) Medina Orellana, Jeancarlo; Torres Arias, Emily Nayeli; Verdugo García, Ligia Mercedes; 1450038383; 1450139058Introduction: Diseases transmitted through food have become a worldwide problem, causing morbidity and mortality and affecting the socioeconomic development of most countries. In 2020, 5890 incidences of bacterial food poisoning were reported in Ecuador, a decrease compared to the previous year, when 12203 cases were recorded. In 2019, these incidents resulted from ingesting food that had been improperly handled and preserved, resulting in the transmission of pathogenic bacteria to consumers. Objective: To evaluate the prevalence of total coliforms and fecal coliforms in strawberries sold in supermarkets and markets in Cuenca. Methodology: A cross-sectional observational analysis was conducted. Samples were collected using a reception form, recording data such as date, temperature, and organoleptic characteristics. Results: As a result, it was determined that 0.39% of samples showed contamination with an unacceptable level of total coliforms (>104 CFU/g), and 37% showed an unacceptable level of E. coli (>102 CFU/g), which are outside the limits established in the Ecuadorian Institute of Standardization (INEN, by its Spanish acronym) 1529-8. Conclusion: The presence of total coliforms and E. coli was determined in supermarkets and markets in Cuenca, showing unacceptable levels, so it is necessary to have correct hygiene practices to ensure food safety.
