Trabajos de Titulación - Bioquímica y Farmacia

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“Estudio comparativo de la calidad biofarmacéutica de diferentes marcas comerciales de tabletas de ibuprofeno 600 mg”
(Universidad Católica de Cuenca., 2024) Reino Bermeo, Kevin Santiago; Arcentales Morocho, Jorge Alfredo; Cárdenas Cordero, Janneth Fernanda; 0150090538; 0150577336
ntroduction: Ibuprofen is one of the most consumed drugs in the world due to its ability to relieve pain, a common condition in many pathologies. Therefore, quality control of this drug is essential to guarantee its safety and efficacy. Objective: To conduct a comparative study of the biopharmaceutical quality of 600 mg ibuprofen tablets of various brands commercially available in the Ecuadorian market, applying physicochemical tests. Methodology: The methodology applied was experimental, cross-sectional, and prospective and was used to control the quality of 4 different commercial brandsof 600 mg ibuprofen. Results: Four ibuprofen brands were evaluated, two generic and two innovative: MK, Ferbertt, Caplin Point, and Genfar. The tablets, with a diameter of 18 to 20 mm, did not present deformations, maintained uniform color and odor, and met the Pharmacopoeia specifications in the weight test. Conclusion: All the tablets evaluated complied with the Pharmacopoeia specifications and did not present significant changes in their biopharmaceuticalquality, becoming stable formulations