Trabajos de Titulación - Medicina Veterinaria
URI permanente para esta colecciónhttps://dspace.ucacue.edu.ec/handle/ucacue/53
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Examinando Trabajos de Titulación - Medicina Veterinaria por Materia "ACEPROMACINA"
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Ítem Acceso Abierto Monitorización hemodinámica en caballos temperamentales mediante el uso de acepromacina a dosis bajas por vía subcutánea(Universidad Católica de Cuenca., 2025) Brito Duran, Bryan Fernando; Landi Torres, Edwin Ernesto; 0106390479; Castillo Zhizpon, Sandra ElizabethAcepromazine (ACE) is a phenothiazine tranquilizer that acts as a dopamine antagonist. The objective of this study was to evaluate the degree of sedation along with the collection of physiological parameters (diastolic pressure, systolic pressure, temperature, and oxygen saturation). Three doses (0.02 mg/kg, 0.04 mg/kg, and 0.06 mg/kg) were administered subcutaneously to euphoric horses in order to determine which of them provides a sedative effect with minimal adverse reactions. The research was conducted in the parish of San Pablo de Shaglli, part of the Santa Isabel Canton, Azuay Province, located at an altitude of 4160 meters above sea level. It is important to note that these conditions impose physiological differences, particularly in oxygen saturation and cardiovascular response. The study involved 18 Creole horses, with one repetition per dose, totaling 54 repetitions. Physiological parameters were recorded before and after ACE administration, with behavioral evaluation performed 20 minutes post-application. The results showed that the ideal dose is 0.04 mg/kg, as it generated a favorable response, proving to be safer and more effective compared to the other doses, especially considering the geographical conditions of the area. The 0.02 mg/kg dose was insufficient, as it produced little to no sedation. On the other hand, the 0.06 mg/kg dose caused excessive sedation, evidenced mainly by a marked and risky drop in blood pressure, which is unfavorable given the environmental conditions. Keywords: acepromazine, equines, altitude, physiological constants
