Estudio comparativo de las características fisicoquímicas y biofarmacéuticas de diferentes marcas comerciales de tabletas de paracetamol 500 mg

Abstract

INTRODUCTION: Tablet control should be carried out during manufacturing and also at the final product, thus ensuring that it complies with the established specifications. These controls generally include physical, chemical, and biopharmaceutical characteristics, ensuring these drugs are quality, safe, and effective. OBJECTIVE: To conduct a comparative study of the physicochemical and biopharmaceutical characteristics of 500 mg paracetamol tablets through physicochemical tests in five different brands distributed in Cuenca-Ecuador. METHODOLOGY: This research work on paracetamol tablets is experimental and uses a cross-sectional approach. RESULTS: The analyzed 500 mg paracetamol tablets present uniformity in terms of their organoleptic characteristics, hardness, friability, disintegration, and weight uniformity tests. The results comply with USP 30 standards, although there was a physical parameter that could affect the friability result. CONCLUSION: The physicochemical and biopharmaceutical characteristics of the analyzed drugs are optimal since these medications previously underwent several controls and filters to be marketed nationally; however, it is essential to consider that environmental factors may influence the obtained data