Actualización en el manejo con Isotretinoína del acne moderado – severo

Abstract

Introduction: Acne is an inflammatory, multifactorial skin disease primarily affecting adolescents and young adults. It is caused by the obstruction of the pilosebaceous follicle due to follicular epidermal hyperproliferation, sebum accumulation, and bacteria. Oral isotretinoin is an essential treatment for severe acne as it regulates cell proliferation and reduces inflammation. Objective: To provide an update on managing isotretinoin in moderate to severe acne, identify the optimal therapeutic dose, and describe its most common adverse effects. Methodology: A comprehensive review of the current literature will be conducted on studies published in scientific journals from 2018 to 2023, selected through the PRISMA method. Results: Among the articles, 63.3% were obtained from the PubMed database, followed by Science and SciELO. Most papers were published in international journals related to dermatology and cosmetology. The distribution of articles by the year of publication varied, with a higher number between 2018 and 2019. Conclusions: Isotretinoin is a highly effective treatment for moderate to severe acne. However, its administration should be supervised to safeguard the patient's health and prevent adverse effects.