Cáncer de mama hereditario relacionado a mutaciones en BRCA1/BRCA2: una revisión sistemática

Abstract

The objective of this work is to carry out a systemic bibliographic review of hereditary breast cancer relatedto BRCA1/BRCA2 Mutations, for which the PRISMA method and a systematic bibliographic review were used, using a qualitative approach and a descriptive study based on a meta reflective study, carrying out an exhaus-tive analysis. Due to the review of relevant information, information about hereditary breast cancer related to BRCA1/BRCA2 mutations was sought. The results indicate that one in eight women will develop breast cancerin their lifetime. This type of cancer may have a genetic origin, and mutations in the BRCA1 and BRCA2 genes have been identified as the main cause of hereditary breast cancer. Likewise, he identified mutations in the BRCA1 and BRCA2 genes as the most common and ha ve been the subject of numerous studies related to susceptibility to breast cancer. Similarly, women carrying these mutations were found to have a significantly increased lifetimerisk of breast cancer,with estimates ranging from 45% to 65% for BRCA1 and 45% to 85% for BRCA2. Finally, it is concluded that when performing the analysis of the articles included in the review,it was determined that nine of the ten scientific articles established the relationship or link between hereditary breast cancer and the presence of BRCA1/BRCA2 mutations. In the same way, it was possible to establish thatthe problem is not only centered on the carrier woman, since genetics could significantly affect a gene-carry-ing daughter, with a 50% chance of also developing breast cancer