Resistencia y Acritud de Pasteurella multocida en gatos domésticos (felis catus) en cuatro clínicas veterinarias del sur de Cuenca

Abstract

Pasteurella multocida is a zoonotic pathogen of high relevance in public health; however, information on its antimicrobial resistance (AMR) profiles and virulence factors in domestic cats is limited. This study aims to contribute to understanding these critical aspects, which are fundamental for developing effective strategies to prevent and control zoonoses. This study evaluates the AMR and virulence factors of P. multocida isolated from the oral mucosa of Felis catus in four veterinary clinics in southern Cuenca. Fifty oral mucosa samples were collected using sterile swabs, and susceptibility to 10 commonly used antimicrobials in veterinary medicine was analyzed. MALDI-TOF mass spectrometry was used to confirm the specific presence of Pasteurella multocida and bacterial load. The results will reveal the AMR profiles and virulence factors of the isolated strains, evaluating their potential zoonotic impact and implications for public health. This research will significantly contribute to the knowledge of the epidemiology of P. multocida in felines, identifying effective antimicrobials, those with resistance, and the present virulence factors. This research will significantly contribute to the knowledge of the epidemiology of Pasteurella multocida in Felis catus populations, identifying antimicrobials with therapeutic efficacy and those for which resistance is evident, as well as virulence factors.

Keywords: Bacteria; Zoonosis; Antimicrobial Agents; Oral Mucosa; Virulence; Public Health; Mass Spectrometry; AMR; Felis Catus; Veterinary Medicine