Alteraciones en la conectividad cerebral asociadas al consumo de Ayahuasca y sus implicaciones en trastornos psicóticos: Revisión sistemática

Abstract

Introduction: Ayahuasca consumption has garnered significant interest due to its effects on brain connectivity and its possible implications in psychotic disorders. Although there are studies on its neurobiological effects, its specific relationship with brain alterations remains little explored. Therefore, a systematic literature review is presented, aiming to consolidate the available knowledge and open new research directions regarding its potential. Objective: To determine the alterations in brain connectivity caused by the consumption of Ayahuasca and its possible implications in the development of psychotic disorders. Methodology: A systematic review will be carried out following the PRISMA 2020 guidelines. Searches will be conducted in PubMed and Taylor & Francis using terms from Descriptors in Health Sciences (DeCS), Medical Subject Headings (MeSH), and Boolean operators for the construction of the search algorithms. Results: Ayahuasca consumption causes alterations in brain connectivity, especially in the default mode network, decreasing its activity. An increase in brain entropy was observed, indicating greater functional disorganization. These alterations are associated with intense psychedelic experiences. In vulnerable individuals, psychotic symptoms may be triggered.