Interleucinas como marcador predictor de gravedad de dengue

Abstract

Introduction: Dengue continues to be a significant problem for global public health. The identification of criteria to determine its severity is crucial. Recently, several biomarkers have been studied, looking for those with a high predictive power for the severity of dengue, which could be key to reducing its morbidity and mortality. Objective: To determine the relationship between interleukins and the severity of dengue. Methodology: The PRISMA methodology was used to develop this systematic review. An extensive search was conducted in Pubmed, Web of Science, and Scopus databases. A group of terms taken from the Medical Subject Heading (MeSH) and the Descriptors in Health Sciences (DeCS) were used: “Interleukins,” “Predictors,” “Prognosis,” “Dengue,” “Severe Dengue,” and “Prognostic value.” Articles in English and Spanish from the last 10 years were used. Finally, the NHLBI tool was used for the bias analysis. Results: It was found that interleukins were elevated in patients with severe Dengue, specifically IL-2 (p<0.01), IL-18 (p<0.001), IL-1ꞵ (p<0. 0001), IL-10 (p=0.034), IL-6 (p<0.005) while IL-8 was elevated in the acute phase and in defervescence (p=0.00 and p=0.01, respectively). These findings suggest that interleukin levels do not have great sensitivity since they can be elevated both in the severity of the disease and in the acute phase. Conclusion: There are several interleukins that can be elevated in different stages of the disease, not necessarily in severity, indicating that these markers could help predict severity, but not to determine a stage.