Histiocitosis de Rosai-Dorfman: revisión bibliográfica

Abstract

Introduction: Rosai-Dorfman Histiocytosis (RDH) is a rare worldwide pathology with a prevalence of 1 per 200,000 inhabitants; it is benign and of unknown etiology. It presents a diverse clinical picture with remarkable similarity to other pathologies, posing a significant challenge in its diagnosis.

It is characterized by emperipolesis in its histology, with an adverse immunohistochemical profile for CD1 and positive for CD68 and S100. Despite various pharmacological treatments, this disease is accompanied by multiple relapses, which give a poor prognosis and complicate its treatment.

Objective: To describe in a general manner the updated knowledge of Rosai-Dorfman Histiocytosis and the therapeutic measures implemented through a review of the literature and evidence-based medicine.

Methodology: Observational study of narrative literature review on Rosai-Dorfman disease.

Conclusion: Understanding RDH will contribute to a better comprehension of the topic and thus enable timely differential diagnosis, allowing for proper disease management.