Diagnóstico y tratamiento clínico del síndrome antifosfolípidico seronegativo

Abstract

The Antiphospholipid Syndrome (APS) was described for the first time in 1982 by the scientist Graham R. V Hughes through careful observations and laboratory data. APS is a multisystem disorder associated with the persistent presence of antiphospholipid antibodies, events thrombotics and maternal-fetal morbidity and mortality. In 2003, Hughes and Khamasht managed to identify an uncommon variable of APS called seronegative, which manifests itself with the characteristic thrombolytic symptoms of this disease, however, there is no positivity in serological tests, because it is a pathology that is difficult to identify. and diagnosis requires special attention since it can lead to multiple complications if it is not treated in a timely manner. General objective: Describe the diagnosis and treatment of seronegative Antiphospholipid Syndrome Methodology: Bibliographic review. Studies with systematic reviews, review articles and meta-analyses with a publication date of the last 5 years in English and Spanish will be included. Virtual bibliographic databases such as Pubmed will be used, the information will be collected using the PRISMA guide, by creating personalized tables each article will be included with the name of its author, place, year of publication and study design. Results: It is expected that this work will be useful to inform the medical community about this pathology and the clinical relevance of its diagnosis and clinical treatment in the prevention of complications associated with thrombotic and obstetric events .