Relación entre la restricción de crecimiento intrauterino y la deficiencia de vitamina D

Abstract

The high prevalence of vitamin D deficiency (VDD) in pregnancy and the studies that have reported fetal growth restriction (IUGR) in pregnant women with low vitamin D concentrations or improvement of the restriction after supplementation with the same guide to the existence of a relationship between the two problems. Articles were searched and analyzed in the PubMed, Science, and Taylor & Francis databases, entering the terms: fetal growth restriction, vitamin D deficiency, pregnancy complications, and maternal nutrition. The physiological anti-inflammatory, pro-angiogenic, and proliferation-regulating effects of vitamin D and its receptor in the fetal-placental unit are impaired in mothers with low serum 1α,25-hydroxyvitamin D levels. Deficient maternal vitamin D concentrations interfere in the evolution of pregnancy and can contribute to the development of IUGR by causing placental insufficiency.