Exacerbación de las convulsiones consecuentes al período menstrual. Epilepsia Catamenial

Abstract

Introduction: Catamenial epilepsy is a neurological disease characterized by increased frequency of seizure presentation during the menstrual cycle, pathophysiologically due to estrogen elevation and progesterone depletion. Diagnosis is mainly clinical, although laboratory criteria are also assessed. Therapeutic management is based on the use of anticonvulsivants and hormonal therapy. Objective: To determine the relantioship between increased seizure frequency and the menstrual cycle. Methodology: This research was perfomed based on PRISMA 2020 systematic verification by searching DeCs and MeSH keywords, Boolean type connections, y u o, and y or in the following databases: PubMed, Medline, ResearchGate, World of Science, Scielo, Elsevier, Redalyc, UptoDate, DocPlayer, BioMed, World Scientific Publishing, ILAE, national to international university repositories. Results: By applying inclusion and exclusion criteria, it included retrospective and descriptive studies, case reports, bibliographic reviews, manuals, and practical guides, in a total of 33 bibliographic references of moderate and high quality. Discussion; When comparing studies, there is no variability in concept, pathophysiology, and diagnosis. However, the lack of research studies, such as current clinical trials regarding therapeutic management, is notable. Conclusions: Catamenial epilepsy is poorly diagnosed due to the lack of knowledge of the relationship between hormonal changes during menstruation and seizure exacerbations. Therefore, the diagnosis is nonspecific and untimely, and the treatmen is currently obsolete. Keywords: seizures, catamenial epilepsy, neuroactive, proconvulsant, neuroprotective