Efectos de la metformina en la microbiota intestinal en pacientes con diabetes mellitus tipo 2

Abstract

Metformin is currently the most widely used oral antidiabetic, it has been shown to modify the characteristics of the intesti-nal microbiota of people with Type 2 Diabetes Mellitus, by altering more than 80 bacterial strains. To determine the effects of metformin on the intestinal microbiota in patients with type 2 diabetes mellitus. A systematic review of the literature was carried out in: SCOPUS, PubMed, Science Direct and Taylor and Francis, the words for the search equation they were obtained through the Descriptors in Health Sciences (DeCS), the selected terms were Metformine, Gut microbiota and Diabetes Mellitus, type 2, inclusion and exclusion criteria were used. Results: Six articles on the effects of metformin on the intestinal microbiota in patients with type 2 Diabetes Mellitus were analyzed, where alterations of the Firmicutes and Proteobacteria phyla were found, with their most representative genera being Clostridium, Lactococcus, Megamonas and Prevotella.. Metformin interacts and modifies the conformation of the intestinal microbiome, contributing to the decrease in blood glucose levels