Utilidad del biomarcador presepsina en el diagnóstico y pronóstico de sepsis y shock séptico

Abstract

Objective: To determine the usefulness of the presepsin biomarker in the diagnosis and prognosis of sepsis and septic shock. Methodology: The type of study that will be carried out is a bibliographic review, which will be made up of articles in English and Spanish that contain relevant information for the review, the selection of articles will be through the databases: Pubmed, Sciendirect, Scopus , Taylor & Francis and Web of Science; the search will be carried out with the terms of the Medical Subject Headings (MesH) of the National Library of Medicine and descriptors in health sciences (DeCS) of Bireme; For the choice of studies, inclusion and exclusion criteria will be applied, the most important being that they are within the period 2018- 2022. Results: It was concluded that presepsin can be used as a biomarker capable of early diagnosis of sepsis and septic shock, because serum values are higher depending on the severity of the condition, additionally it is important to note that with respect to the Sensitivities and specificities ROC curves were found between 0.688-1 in adults, and 0.887-099 in adults. Conclusion: Presepsin is very useful in the diagnosis and prognosis of patients with sepsis and septic shock, because its serum values allowed differentiating between sepsis and septic shock, it is also important to highlight its prognostic value where it was possible to correlate that at higher levels of presepsin, the percentage of non-survivors is higher, while lower presepsin values were related to better survival.