Abordaje del síndrome de superposición en neoplasias mieloproliferativas crónicas

Abstract

Overlap syndromes represent a diagnostic and therapeutic challenge within the field of hematology, especially in pathologies affecting the hematopoietic stem cell, such as myeloproliferative neoplasms (MPN) and myelodysplastic syndrome (MDS). Thus, a new category of neoplasms known as superimposed MDS/MPN has emerged, which includes five pathologies, the most outstanding being chronic monomyelocytic leukemia, from which the other four subtypes are derived: clonal monocytosis of undetermined significance, atypical chronic myeloid leukemia, MDS/MPN with thrombocytosis, and unclassifiable MDS/MPN. Their variations lie in the genetic mutations they present. Due to this series of cytogenetic and molecular alterations, a literature review is projected to organize and synthesize the most updated information on superimposed MDS/MPN to explain the diagnostic characteristics and the therapeutic approach used in these pathologies