Uso de ácido ascórbico, hidrocortisona y tiamina como coadyuvante en el manejo de sepsis y shock séptico

Abstract

Treating sepsis and septic shock involves using broad-spectrum antibiotics, vasoactive drugs, corticosteroids, fluid therapy, and other drugs to improve the patient's hemodynamic status. Worldwide and in Ecuador, mortality in the Intensive Care Unit due to sepsis and septic shock has increased recently. Using ascorbic acid, thiamine, and hydrocortisone as adjuvants in managing sepsis and septic shock is a novelty in treatment since it interferes with the anaerobic metabolic processes involved in septic patients. This descriptive bibliographic review aims to comment on using ascorbic acid, hydrocortisone, and thiamine as part of the updated treatment for managing sepsis and septic shock. The information was collected through scientific search engines such as PubMed, SpringerLink, and Trip Medical Database of the last five years related to the established theme; studies carried out in humans without the restriction of age or ethnicity. In conclusion, using ascorbic acid, thiamine, and hydrocortisone as adjuvants in managing sepsis and septic shock has not shown significant relevant results regarding decreased mortality or days of hospitalization. However, in particular studies, reductions have been seen in SOFA score, procalcitonin, and serum lactate levels, constituting a practice of use not well established, which needs further investigation to determine whether or not its use.