Estudio de Antraquinonas Sintéticas como Potenciales Inhibidores de la Enzima Beta-Glucuronidasa en Escherichia Coli

Abstract

The beta-glucuronidase enzyme of bacteria such as E. coli is responsible for adverse reactions at the intestinal level of some drugs used in chemotherapy, which causes some patients to abandon their treatments. For this reason, it is necessary to search for agents that can act as inhibitors of this enzyme. In this study we present the experimental results of the evaluation of the potential of synthetic anthraquinones in the inhibition of the enzyme beta-glucuronidase of E. coli, one of the most abundant species in the intestine. Under the conditions employed and at the concentrations tested anthraquinone, 1,8-dihydroxyanthraquinone, 1,2-dihydroxyanthraquinone, 1,5-dinitroanthraquinone, 1-chloroanthraquinone, 2-chloroanthraquinone, 1,8-dichloroanthraquinone, 1,5-dihydroxyanthraquinone, 1,5-dichloroanthraquinone, 1,8-dihydroxy-4,5-dinitroanthraquinone were not able to inhibit the activity of this enzyme. Furthermore, in silico toxicity predictions of each anthraquinone using the PROTOX-II program indicate that the compounds exhibit low hepatotoxic and cytotoxic potential, intermediate carcinogenic and immunogenic potential and high mutagenic potential. This study is a starting point for future research aimed at evaluating anthraquinones as potential inhibitors of the beta-glucuronidase enzyme of E. coli.