Interacción de citoquinas pro inflamatorias en alteraciones emocionales como la depresión: una revisión bibliográfica.

Abstract

Introduction: The interaction of pro-inflammatory cytokines and depression involves an interdisciplinary approach that combines immunology, neuroscience, psychology, and psychiatry. It allows for a more complete understanding of how biological and emotional processes are interconnected, which can lead to more effective therapeutic approaches.

Objective: To investigate the interaction of pro-inflammatory cytokines in emotional disorders such as depression by reviewing scientific research from the last six years.

Methodology: A descriptive method is applied, and a bibliographic review was carried out in which different studies are analyzed regarding the interaction of pro-inflammatory cytokines in emotional alterations, such as depression.

Results: Through the investigation and compilation of different studies, it is corroborated that there is an increase in cytokines in patients with depressive disorders, among the most representative being IL-1β, IL-6, IL-10, which exerts an imbalance in the immune system, endocrine system directly into the hypothalamic pituitary adrenal axis.

Conclusion: There is a total increase in specific cytokines in patients with depressive disorders that stimulate inflammation and cellular stress, causing the body to maintain a state of crucial homeostatic imbalance. When this prolonged state persists, it can induce neuropsychiatric disorders that need to be studied more deeply.