Hepatotoxicidad inducida por la administración en pacientes diabetes mellitus II

Abstract

Introduction: Diabetes mellitus type II is one of the diseases that has generated great concern at the health level, it is estimated that internationally affects more than 415 million people, while in Ecuador it has a high prevalence, where 1 in 10 people between 49 to 60 years suffer from it. In this sense, it is of great relevance to choose an adequate treatment when using antibiotics since this can generate unwanted effects such as hepatotoxicity, which can cause liver damage by developing diseases such as hepatic cell necrosis, hepatitis, cholestasis, granuloma, cholestasis, among others (1,2). Objective: To determine antibiotic-induced hepatotoxicity in patients with diabetes mellitus II. Materials and methods: Qualitative, exploratory, retrospective, descriptive, descriptive, cross-sectional cohort research. For the search of information, we used keywords such as hepatotoxicity, types of hepatotoxicity, classification, diabetes mellitus (I and II), antibiotics, and hepatic lesions by drugs. The search was based on recognized search engines such as Medline, PubMed, Science Magazine, ProQuest, ScieLO, Redalyc, Google Scholar, IntraMed. Results: Cases of hepatotoxicity may occur in 1-10 patients per 100,000 prescriptions; these factors may have a higher incidence in people at risk, as is the case of diabetes. Conclusion: For adequate treatment with antibiotics, a correct evaluation of the patient should be carried out considering his characteristics. Few studies correlate antibiotic hepatotoxicity in diabetic patients.