Efectividad del trasplante de microbiota como tratamiento en adultos de 19 a 70 años con hígado graso no alcohólico: una revisión sistemática

Abstract

Importance: Non-alcoholic fatty liver disease is currently a public health problem due to its high prevalence worldwide. Therefore, different treatment alternatives are being sought, focused on different therapeutic targets, such as fecal microbiota transplantation, which has shown significant advances as an adjuvant treatment to the basic treatment. Objective: The aim of this study was to evaluate the effectiveness of microbiota transplantation as a treatment in adults aged 19 to 70 years with non-alcoholic fatty liver disease. Methodology: A systematic review was carried out following the criteria of the PRISMA protocol. The search was carried out in the databases PubMed, Web of science, Scopus and SciELO. The ROBINS-I tool was used to assess quality. Results: Seven articles were included, of which two of the selected studies were randomized controlled clinical trials, two prospective cross-sectional studies, one cohort study and two case-control studies. Non-alcoholic fatty liver showed increased intestinal permeability and decreased microbial diversity. Adult patients undergoing fecal microbiota transplantation demonstrated improvement in these alterations. Conclusions: Fecal microbiota transplantation is a good treatment alternative in conjunction with nutritional treatment, to decrease the progression of nonalcoholic fatty liver disease.