Diagnóstico y manejo de la nefritis tubulointersticial aguda: revisión bibliográfica

Abstract

Importance: Acute Tubulointerstitial Nephritis (ATIN) is an essential renal condition with an increasing prevalence, particularly among the older population. The association of certain drugs such as antibiotics, proton pump inhibitors (PPIs), and nonsteroidal anti-inflammatory drugs (NSAIDs) with ATIN underscores the imperative need for a thorough review of current diagnostic methods and management strategies. Observations: Through a comprehensive literature review, the prevalence, incidence, and risk factors associated with ATIN were identified, evidencing a remarkable correlation with the use of certain medications. In addition, current and potential management strategies and treatments for ATIN were explored, ranging from pharmacological interventions to lifestyle modifications. It also highlighted the complications inherent to ATIN and their impact on patient prognosis, emphasizing the necessity for early diagnosis and appropriate management. Conclusions and Relevance: The review findings underscore the critical need for an early diagnostic approach and appropriate management of ATIN to prevent progression to chronic kidney disease. Current and emerging management strategies, including timely withdrawal of the causative drug and corticosteroid therapy, are identified as essential to mitigate the impact of ATIN. This review provides an up-to-date and in-depth understanding of clinically relevant for the early detection and effective management of ATIN, thereby improving the quality of life for affected patients.