Biomarcadores de disfunción endotelial como predictores de mortalidad por sepsis en niños

Abstract

Introduction: Sepsis is a leading cause of morbidity and mortality in infants. Previous research in the pediatric literature has shown that Ang-2 levels are associated with sepsis and correlated with the severity of the disease. Applying these biomarkers to treat of sepsis is transitioning from "one-off" supportive therapy to individualized or personalized treatment based on specific patient endotypes.

General Objective: To identify the biomarkers of endothelial dysfunction as predictors of mortality in children with sepsis.

Methodology: It is a descriptive study consisting of a bibliographic review focusing on biomarkers of endothelial dysfunction as predictors of sepsis-related mortality in children. The data search was conducted in scientific databases, including articles published between 2018 and 2022.

Results: In pediatric patients with sepsis or septic shock, the elevation of biomarkers such as Syndecan-1, Ang-1 and 2, and Endocan were found to be predictive of mortality. However, the studies did not provide specific cut-off points or sensitivity and specificity values for the biomarkers due to variations in resources, population, and the biomarkers being studied.

Conclusions: There is a large selection of population studies in which different endothelial biomarkers have been evaluated as predictors of mortality in pediatric patients, with promising findings for clinical practice.