Biocicatrización del extracto de Jungia Rugosa less sobre heridas quirúrgicas en conejos

Abstract

ABSTRACT Jungia rugosa, known as Human Meat, is a medicinal plant native to the Andes. It has been used ancestrally for the healing of wounds; its anti-inflammatory, antimicrobial, and healing properties are related to its content of flavonoids and polyphenolic compounds. This study evaluated the healing effect of Jungia rugosa extract on postsurgical wounds using nine rabbits as biological models. Two semi-solid creams at 5% and 10% were prepared with its extract, which were compared with the traditional use of the plant. The non-invasive surgical procedure consisted of the creation of three 2cm surgical wounds in different anatomical areas (loin, right and left scapula). The rabbits were randomly assigned to three treatment groups: T1 (5%), T2 (10%), and T0 (Control), achieving complete wound healing eight days after the start of healing. Despite not observing statistically significant differences in the healing process between the traditional use of the plant and the cream, the healing obtained by the use of Jungia rugosa proved to equal and/or exceed the results obtained with other commercial products. It was determined that treatment T1 (5%) offers higher quality healing, indicating that the application of creams could be an effective alternative to take advantage of the medicinal properties of this plant. This choice is based on the limitation of being unable to preserve or store the macerates produced in the field, which could promote greater use of the plant in future research. Keywords Jungia Rugosa, Flavonoids, Polyphenolics, Biohealing, Oryctolagus cuniculus