Uso del volumen plaquetario medio como predictor de sepsis neonatal

Abstract

Antecedents: Neonatal sepsis is a public health concern and is a common cause of infant morbidity and mortality. There are several inflammatory biomarkers to predict sepsis. Nowadays, the mean platelet volume is being studied as an accessible and rapid diagnostic predictor in neonates. This study aims to determine the usefulness of mean platelet volume as a predictive indicator in neonatal sepsis situations. Materials and Methods: A systematic review was conducted following the guidelines established by PRISMA. To search for information, databases such as PubMed, Scopus, and Web of Science were considered. The data obtained was limited to the last five years, and a manual search was elaborated using the journals classified in the Q2-Q4 quartiles according to the Scimago Journal & Country Rank. In total, 13 investigations that satisfied the selection criteria were included. Results: The mean platelet volume had a cut-off point between 7.44-10.8 fl with a sensitivity of 37-5-100% and a specificity of 33.7-100% to predict neonatal sepsis. Neonates with sepsis had significantly higher levels of this biomarker relative to non-septic neonates. Conclusion: Mean platelet volume is considered a complementary diagnostic alternative for suspected neonatal sepsis due to its sensitivity and specificity, especially in places with limited resources. Therefore, it is a valuable tool in predicting this condition.