Biomarcadores sanguíneos determinantes de Síndrome de Coronario Agudo

Abstract

Introduction: Acute Coronary Syndrome is a pathology spread worldwide; it is considered one of the ten main causes of morbidity and mortality, which is an extremely worrying fact. It is important to diagnose ACS in a short period, based on clinical, EKG and blood biomarkers that help in confirming symptoms and provide appropriate treatment, thereby improving the chances to survive. Objective: To determine the significance of blood biomarkers in Acute Coronary Syndrome. Methodology: We searched several scientific platforms with recognized academic credibility, such as NCBI, Medscape, UptoDate, JAMA, etc. Bibliographical resources comparing blood-derived cardiac biomarkers and their effectiveness had been used. Results: according to data gathered, the most effective and widely used biomarker worldwide remains the troponins, although the ultra-sensitive troponins (hscTnT and hscTnI) have shown greater effectiveness compared to conventional troponins (Tnl and TnT) in detecting ACS. The cMybp-C was shown to have the same efficacy as hs-cTnT but greater than hs-cTnI and conventional troponins. Conclusions: Troporuns are still at present still the heart biomarkers of election for their low cost and high accuracy, availability and high level of specificity. Ultra-sensitive troponin demonstrated greater efficacy in diagnosing ACS compared to conventional troponins, which are not widely used nationwide. According to studies, cMybp-C showed similar effectiveness to hs-cTnT and higher than hs-cTnI and conventional troponins.