La hiperuricemia como predictor y herramienta de tamizaje para preeclampsia

Abstract

Preeclampsia is considered one of the leading causes of perinatal morbidity in Ecuador, occurring in approximately 8.3% of pregnancies and responsible for 14% of infant deaths. It has been suggested that uric acid plays a role in the development of preeclampsia. However, there is still no solid evidence to support this theory, but it could be considered as an additional tool in the screening of preeclampsia, allowing health personnel to identify and treat this complication early. The present review aims to describe hyperuricemia as a predictor and screening tool for preeclampsia. The main observations obtained were the elevation of serum uric acid concentration preceded by a hypertensive state in pregnant women, especially during the first trimester, especially in complicated pregnancies and at high risk of developing preeclampsia. In addition, it has been suggested that the measurement of this and other biomarkers that contribute to oxidative stress may help in the early control and treatment of the disease. It is concluded that hyperuricemia may be useful as a possible predictor and screening tool for preeclampsia, allowing to determine the severity of the pathology and the occurrence of complications.