Eficacia de las células estromales mesenquimales (MSC) como tratamiento para pacientes con enfermedad obstructiva crónica (EPOC): Revisión sistemática

Abstract

Objective: To determine the efficacy of treatment with mesenchymal stromal cells (MSC) in patients with chronic obstructive pulmonary disease (COPD).Materials and methods: Descriptive, cross-sectional analysis, oriented towards a systematic review of articles in English, published during the last 6 years, in databases such as: PubMed, ScienceDirect, ClinicalTrials.gov; through the use of descriptors (DeCS) and Boolean operators such as: “Mesenchymal Stromal Cells ̈ AND ̈Therapy ̈ AND ̈COPD ̈.Results: It was determined that MSCs are promising for therapeutic applications in COPD, given the ease of obtaining them, their low immunogenicity, their tissue repair properties, and immunomodulation.Conclusions: The success of this therapy weeks or months after MSC therapy will depend on the phase of the disease, the presence of exacerbations and risk factors associated with each patient.