Papel del estrés oxidativo y opciones terapéuticas en infección por SARS COV-2

Abstract

Introduction: elevated levels of oxidative stress in patients with SARS-CoV-2 infection generate tissue damage, causing organ dysfunction and generating a suitable environment for viral replication. Aim: to describe the mechanisms by which oxidative stress is generated in patients with Sars-Cov-2 and its therapeutic options. Methodology: a non-experimental and narrative study of bibliographic review type was carried out, data will be collected from original articles in indexed journals using the PubMed database. Results: patients with SARS-CoV-2 infection present elevated levels of oxidative stress, on the contrary, the levels of antioxidant agents are depleted, increasing the degree of oxidative stress to a greater extent. The use of N-acetylcysteine in a COVID-19 positive patient is a subject under discussion since, although there are inconsistencies in its degree of efficacy, no adverse effects of any kind have been observed. Conclusions: there are antioxidant therapeutic options under study, however, despite having a high safety profile, their efficacy in the treatment of COVID-19 is still unproven.