Efectividad de la carbetocina versus oxitocina en el tratamiento de la hemorragia postparto: revisión sistemática

Abstract

Background: Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality, particularly in low- and middle-income countries. Oxytocin and carbetocin are the primary recommended treatments; however, uncertainty remains about which is more effective in reducing maternal mortality and blood loss. Objective: To compare the effectiveness of carbetocin versus oxytocin in treating PPH through a systematic review of observational studies, analyzing various risk factors and reducing blood loss. Methods: A systematic review will be conducted following PRISMA guidelines. Studies will be searched in databases such as PubMed, SciELO, ScienceDirect, and Cochrane, focusing on direct comparisons between carbetocin and oxytocin in women with PPH. Study selection will be performed using the Rayyan platform, and quality assessment will be conducted using the ROB 1 and ROB 2 tools. Expected Results: This study aims to determine whether carbetocin is more effective than oxytocin in reducing maternal mortality and blood loss. Conclusion: This systematic review will provide evidence-based insights into the comparative efficacy of these treatments, offering a better perspective on clinical practices for managing PPH, especially in resource-limited settings. Keywords: carbetocin, postpartum hemorrhage, oxytocin