Insulina vs heparina en el tratamiento de la pancreatitis aguda secundaria a hipertrigliceridemia

Abstract

Introduction: Hypertriglyceridemia is considered one of the main causes of acute pancreatitis worldwide. This disease is closely related to acute pancreatitis. The prevalence of pancreatitis induced by hypertriglyceridemia has been reported in up to 22% of cases. General objective: To analyze the use of insulin vs heparin in the treatment of acute pancreatitis secondary to hypertriglyceridemia. Methods: Systematic review using PubMed Central, Elsevier, Scopus, Web of Science databases. Scientific articles published during the period 2018-2023 in Spanish and English, and indexed in Journal Citation Reports and/or Scimago Journal & Country Rank (quartiles 1 to 4), were included. Results: For the treatment of pancreatitis induced by hypertriglyceridemia, it has been shown that insulin and heparin are effective in reducing serum TG levels. However, caution should be used with heparin, as there may be potentially adverse effects with LPL depletion, in addition to the risk of bleeding. Conclusions: Patients with hypertriglyceridemia-induced pancreatitis tend to have a more severe course of acute pancreatitis than patients with other pancreatitis, so initial support and adequate fluid resuscitation should begin immediately. Insulin and heparin have been shown to be effective in reducing serum triglyceride levels.