Linfomas doble y triple HIT; como factor de mal pronóstico en Linfoma difuso de células B grandes

Abstract

Introduction: Double- and triple-hit diffuse large B-cell lymphoma (DLBCL) is a hematological malignancy with a MYC, BCL 2, and/or BCL 6 gene rearrangement. Currently, these lymphomas have an incidence of 8% concerning all cases of DLBCL. Unfortunately, its prognosis is generally negative, with a one-year survival rate due to its high aggressiveness because of the conflicting genetic rearrangement and the difficult late diagnosis, treating this pathology as a simple non-Hodgkin lymphoma. Objective: The research aims to study the prognosis of double (DHL) and triple hit (THL) diffuse large B-cell lymphoma. Methodology: A narrative bibliographic review was conducted, collecting information and scientific evidence through the biomedical database PubMed, especially updated English articles from the last five years. Results: This research aimed to demonstrate with scientific information the extremely unfavorable prognosis in patients with double- and triple-hit lymphoma, as well as a low overall survival rate and progression-free survival.