Aplicación de tecnología de edición de genes como alternativa de tratamiento en pacientes con VIH

Abstract

Human immunodeficiency virus (HIV) is characterized by progressively damaging the immune system, which is why therapeutic methods have been developed over the years to alleviate the symptoms presented by patients. However, these methods do not eradicate the disease. Gene therapy is a promising alternative when it comes to virus eradication, as it proposes gene editing to eliminate the virus from the cell. Currently, new therapeutic strategies are being explored, such as the use of gene editing technology, to reduce viral replication and eliminate HIV from the human genome. Improving adherence to antiretroviral treatment (ART) is important, and the impact of side effects on adherence is being reviewed. Knowledge about ART can moderate the relationship between side effects and adherence. In general, the findings of this review suggest that continuous research is necessary to find alternative HIV treatments and improve the quality of life for people living with this disease. The new therapeutic strategies show promise, but further studies are needed to evaluate their safety and efficacy. Improving adherence to ART remains a significant challenge, and effective interventions are needed to enhance adherence and prevent drug resistance. In conclusion, the findings suggest that gene therapies have great potential to improve the quality of life for people living with HIV/AIDS and enhance the effectiveness of antiretroviral treatment.