Síndrome de Heyde asociado al factor de Von Willebrand

Abstract

Introduction: Heyde's syndrome is a disorder that was described for the first time in 1958. This disorder can cause high mortality and morbidity rates if the correct diagnosis is not made. Objectives: Bring up an approach of Heyde Syndrome to focus the attention of different researchers and provide a compilation of updated information for a better understanding of the topic. Methods: Articles such as Meta-Analysis, Bibliographic Reviews, Systematic Reviews and clinical tests were taken in consideration for this article, leaving behind articles that did not meet the inclusion criteria mentioned before. MeSH terms such as: "Aortic stenosis AND Gastrointestinal AND Hemorrhage AND Syndrome AND Von Willebrand” were used for the search. Results: Heyde's syndrome usually occurs at advanced ages, there are not enough studies, therefore there is no data for this disorder, making it difficult to diagnose. Aortic stenosis in Heyde's syndrome is a key finding when it is accompanied by gastrointestinal bleeding. Demonstrating that aortic stenosis is related to metalloprotease activity producing a Von Willebrand proteolysis. Conclusion: Heyde's syndrome is a complicated pathology, with characteristic signs and symptoms such as aortic stenosis, gastrointestinal bleeding and anemia. Surgically placed or transcatheter prostheses can improve the severity of this pathology, especially in patients with advanced aortic stenosis.