Glomerulonefritis rápidamente progresiva en un paciente con linfoma no Hodgkin. Reporte de caso

Abstract

Introduction: the coexistence of Non-Hodgkin Lymphoma (NHL) and rapidly progressive glomerulonephritis (RPGN) poses an uncommon but significant clinical challenge. Clinical Case: this is about a 24-year-old male patient who presents with a laryngeal tumor and an ulcerative lesion on the lip, accompanied by unexplained weight loss. He was admitted to the Vicente Corral Moscoso Hospital with respiratory failure, acute renal failure, and an urgent need for dialysis. Analyses revealed alveolar hemorrhage, leukocytosis, anemia, elevated transaminases, and alterations in complement levels. He tested negative for antineutrophil cytoplasmic antibodies (ANCA), and characteristics suggestive of lymphoma were found in a tumor biopsy of the hypopharynx (likely T lymphoblastic). The treatment was palliative based on the patient's symptoms with in-hospital corticosteroids, which temporarily improved his condition. However, he could not recover and passed away. Conclusion: T lymphomas are a rare type of neoplasm, which can often be asymptomatic depending on their location, making the diagnosis challenging due to their atypical clinical presentation. In the case of glomerulonephritis related to non-Hodgkin lymphoma, the kidneys can be affected in various ways. It is advisable to perform an early renal biopsy for diagnosis and staging. Timely treatment is essential for disease remission.