Síndrome nefrótico secundario a tiroiditis de Hashimoto. Revisión Sistemática.

Abstract

Background: Several studies have shown that a significant percentage of patients with Hashimoto's thyroiditis present nephrotic syndrome as the main manifestation. General Objective: To describe the relationship between nephrotic syndrome secondary to thyroid dysfunction through the analysis of relevant articles. Specific Objectives: To identify the etiology involved in the development of nephrotic syndrome in patients with Hashimoto's thyroiditis, to interpret both immunological and non-immunological interactions between the thyroid and renal parenchyma, and to evaluate how early treatment of autoimmune thyroiditis may prevent a nephrotic syndrome. Methods: A search was conducted across various databases, including PubMed, Scopus, Google Scholar, SciELO, UpToDate, and DynaMed. Articles published in the last five years in English and Spanish were included. Results: A total of 30 articles were analyzed, of which 56% were from Google Scholar, 23% from PubMed, 14% from Scopus, and 1% from SciELO. Conclusions: The correlation between Hashimoto’s thyroiditis and nephrotic syndrome is complex and influenced by several factors. The association between both conditions is highlighted here, especially with membranous nephropathy, which is one of the main causes of nephrotic syndrome. Furthermore, the interrelationship between the thyroid and kidney underscores the importance of a collaborative approach in the evaluation and management of these conditions to provide comprehensive treatment to affected patients. Keywords: Hashimoto’s thyroiditis, hypothyroidism, nephrotic syndrome, interaction, relationship