Eficacia del Olmesartán en comparación con el Perindopril en el control de la Hipertensión Arterial: Revisión Sistemática

Abstract

Title: Efficacy of olmesartan compared with perindopril in the control of arterial hypertension: a systematic review.

Objective: To analyze the comparative efficacy of olmesartan and perindopril in the treatment of hypertension in adults, with the purpose of providing scientific evidence to support clinical and therapeutic decisions.

Methodology: Studies in English and Spanish from the past five years that evaluated the medications olmesartan and perindopril in patients with hypertension were reviewed. Reviews, case reports, and studies without a scientific basis were excluded. Three scientific databases were used to search for information: PubMed, Taylor & Francis, and Web of Science. Risk of bias assessment was assessed using RoB 2 tools and Joanna Briggs Institute (JBI) critical appraisal tools.

Results: Several clinical and observational studies were analyzed. Both drugs were effective in reducing blood pressure. Olmesartan was better tolerated and had a lower incidence of cough, while perindopril combined with other medications, such as indapamide and amlodipine, showed a greater reduction in blood pressure.

Discussion: The lack of direct head-to-head comparisons between the two drugs limits the ability to reach a definitive conclusion; the analyzed studies show methodological heterogeneity and a risk of indirect bias. Therefore, higher-quality evidence is required.

Conclusions: Both drugs are effective and safe, thus the choice of medication must be individualized according to the patient's needs. Furthermore, direct comparative studies are recommended.