Niveles de IgG post vacunación SARS-CoV-2 Tipo ARN Vs. Vectores Víricos y vacunas inactivadas. Revisión Sistemática.

Abstract

OBJECTIVE: To determine IgG levels post-SARS-CoV-2 vaccination with mRNA vaccines compared to viral vectors and inactivated vaccines. MATERIALS AND METHODS: This systematic review is based on the 2020 PRISMA statement guidelines. Articles were searched in PubMed, Scopus, and Web of Science databases; CONSORT and STROBE scales were employed to assess the quality and bias of selected articles. RESULTS: After applying inclusion, exclusion, and selection criteria, 127,452 articles were obtained; 24 full-text articles were registered, 54% with low bias and 46% with medium bias. The variables considered included vaccine type, follow-up time, and post-vaccination IgG levels. The results showed that mRNA vaccines got a better immune response with higher antibodies than viral vector and inactivated vaccines. It was confirmed that the immune response increases with booster doses of the mRNA vaccine. CONCLUSIONS: IgG values after mRNA vaccination reached 9356 AU/ml three months after the first dose. For viral vector vaccines, a maximum value of 626 AU/mL was found four months after the first dose, and antibodies detected in the inactivated vaccine were 131 BAU/mL three months after the third dose.