Examinando por Autor "Urgiles Rolland, Jorge Thomas"
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Ítem Acceso Abierto Consumo de cafeína y anomalías congénitas: Revisión sistemática(Universidad Católica de Cuenca., 2025) Urgiles Rolland, Jorge Thomas; Ríos Romero, Kimberly Aniana; Muñoz Cajilima, Juan Pablo; 3040090023; 1719559484Introduction: Caffeine consumption produces effects on the fetus during pregnancy; however, the relationship between these changes and the appearance of congenital malformations is not entirely clear. Therefore, early detection of caffeine consumption in all pregnant women and women of childbearing age is encouraged to limit its consumption and prevent malformations. Objective: To determine the association between caffeine consumption during pregnancy and congenital anomalies. Methodology: A systematic review was conducted using the PRISMA 2020 statement. For this purpose, the search was performed in PubMed, Web of Science, and Scopus databases. The articles were selected using eligibility criteria, and the risk of bias was assessed using the ROBINS-I tool. Results: The results indicate that coffee consumption is associated with oral and craniofacial malformations, although some studies did not find this relationship. Adverse effects of caffeine on fetal blood flow, metabolism, increased amniotic fluid volume, cardiac and genital abnormalities, and low birth weight were also identified; however, other studies did not observe adverse effects with low doses of caffeine. Furthermore, coffee consumption has been associated with decreased fetal bone density and neurological alterations. Finally, although the evidence is limited, some studies suggest possible genetic alterations associated with caffeine consumption. Discussion: Pregnancy is a dynamic process influenced by internal and external factors, including diet. Some studies suggest that caffeine consumption is associated with oral and craniofacial malformations, cardiac, fetal growth, neurological, and genetic alterations. However, other studies do not find these relationships, and several present a high risk of bias. These limitations highlight the need for more rigorous and well- designed research to clarify the effects of caffeine on embryonic development. Conclusion: The systematic review reveals that coffee consumption is associated with oral and craniofacial malformations, cardiac, vascular, and neurological alterations in fetuses, low birth weight, and decreased bone density. Although some studies found that there is no relationship with certain anomalies and that low doses of caffeine seem not to have negative effects, the general evidence suggests possible risks for embryonic development.Ítem Acceso Abierto Relación de la microbiota intestinal en patologías cutáneas(Universidad Católica de Cuenca., 2023) Falcon Cabezas, Angel Ramiro; Urgiles Rolland, Carlos Rolando; 1004601561; Urgiles Rolland, Jorge ThomasThe intestinal microbiota is made up of more than a million microorganisms, among which bacteria are the most prevalent. This microbiota depends directly on the exact location along the digestive tract, with the portion of the colon being the one that houses the largest amount of the micro-organism of the flora. The microbiota of the skin is directly related to the microbiota of the intestine due to the various mechanisms that exist in its formation. The objective of this study was to analyze the use of probiotics and prebiotics in the treatment of skin diseases and the relationship between the intestinal microbiota and skin diseases. A narrative bibliographic review of the scientific literature on the relationship of the intestinal microbiota in skin pathologies was carried out. It was concluded that the use of probiotics and prebiotics play an important role in skin disease, especially inflammatory type
