Trabajos de Titulación - Sede Azogues - Medicina
URI permanente para esta colecciónhttps://dspace.ucacue.edu.ec/handle/ucacue/89
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Examinando Trabajos de Titulación - Sede Azogues - Medicina por Asesores "Pérez Ramírez, Jacinto Eugenio"
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Ítem Acceso Abierto Nuevos Antirretrovirales para el tratamiento del VIH. Revisión sistemática(Universidad Católica de Cuenca., 2024) Rivas Ordóñez, Adriana Lizeth; Pérez Ramírez, Jacinto Eugenio; 1900458751Background: The introduction of new antiretrovirals (ARVs) has transformed Human Immunodeficiency Virus (HIV) treatment, improving efficacy and tolerability. Evaluating these new regimens is essential to understand their impact in different clinical settings. Objective: This systematic review aims to analyze the effectiveness and safety of new ARVs regimens approved for HIV-1 treatment, comparing their performance with treatments. Methodology: A comprehensive search was conducted in databases such as PubMed, Cochrane Library, and Embase, including studies published in 2019. Studies were evaluated according to PRISMA guidelines, and the Cochrane Risk of Bias tool was used to assess their quality. Results: The new ARVs demonstrated greater efficacy in viral suppression and a superior safety profile, with fewer serious side effects than traditional treatments. In addition, the reduced pill burden favored greater adherence to treatment. These regimens were effective in diverse populations, including those with drug resistance or previous treatment failures. Conclusion: The new ARV regimens improve viral suppression and tolerability and simplify treatment, facilitating adherence and adapting to different patient profiles. It suggests that they could become the first choice in HIV-1 treatment. Keywords: HIV, antiretrovirals, compliance and adherence to treatment, side effects, systematic reviewÍtem Acceso Abierto Tratamiento antimicrobiano en shock séptico. Revisión sistemática.(Universidad Católica de Cuenca., 2024) Padilla Padilla, Angélica Estefanía; Pérez Ramírez, Jacinto Eugenio; 0150700623Introduction: Sepsis is a dysregulated body response to an infection, resulting in a systemic immune response that can progress to septic shock if not managed promptly and appropriately. Bacteria are the main causal agents, with Staphylococcus aureus being the most common pathogen in 77% of cases, followed by Streptococcus pneumoniae in 45%. The severity level depends on the setting in which the individual was infected, increasing the importance of hospital emergency departments in recent years for timely detection and the application of new clinical practice guidelines. These guidelines assess the level of compromise and mortality risk and the need for early and adequate treatment. Objective: To identify the antimicrobials currently used in septic shock. Methodology: A systematic review of septic shock and the antimicrobials used was conducted through a literature search of scientific articles, following the PRISMA 2020 guidelines, using databases such as Taylor& Francis, Redalyc, SciELO, Scopus, PubMed, Web of Science, and Science Direct. Conclusions: Diagnostic methods are crucial for timely and appropriate treatment based on each patient’s severity. According to current guidelines, the most commonly used antimicrobials are cephalosporins and carbapenems, administered as monotherapy or in combination therapy. Early empirical treatment in suspected septic shock cases significantly reduces mortality rates. Keywords: shock, sepsis, multi-organ, antimicrobial
