Trabajos de Titulación - Sede Azogues - Medicina
URI permanente para esta colecciónhttps://dspace.ucacue.edu.ec/handle/ucacue/89
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Examinando Trabajos de Titulación - Sede Azogues - Medicina por Asesores "Calle Gutiérrez, María Silvana"
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Ítem Acceso Abierto Efectividad del febuxostat en pacientes hiperuricémicos. Revisión sistemática(Universidad Católica de Cuenca., 2024) Calle Crespo, Víctor Manuel; Calle Gutiérrez, María Silvana; 0303097224Hyperuricemia is a chronic, treatable condition caused by the deposition of monosodium urate crystals in joints and periarticular tissues due to elevated serum uric acid levels. This disorder is associated with various comorbidities and an increased risk of cardiovascular disease. Pharmacological management of hyperuricemia includes xanthine oxidase enzyme inhibitors, with febuxostat demonstrating beneficial effects in this pathology. Objective: To determine the effectiveness of febuxostat in hyperuricemic patients. Methods: A systematic review was conducted using the PRISMA 2020 methodology. This descriptive study was based on scientific literature from databases such as PubMed and Taylor & Francis, utilizing freely accessible articles indexed in SCImago Q1 and Q2 quartiles regarding febuxostat's effectiveness in hyperuricemic patients. Results: Twenty scientific documents were identified following a search that applied eligibility criteria and a meticulous analysis of each article's abstracts, results, and conclusions. These included 17 randomized controlled clinical trials, two prospective cohort studies, and one retrospective cohort study. Conclusions: Febuxostat's effectiveness was observed compared to allopurinol, topiroxostat, and placebo. The study demonstrated that febuxostat improves glomerular filtration and provides vascular protection by reducing serum uric acid levels. Keywords: effectiveness, febuxostat, inhibitor, xanthine oxidase, hyperuricemia
