Medicina Veterinaria
URI permanente para esta comunidadhttps://dspace.ucacue.edu.ec/handle/ucacue/52
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Examinando Medicina Veterinaria por Asesores "Castillo Hidalgo, Edy Paul"
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Ítem Acceso Abierto Administración de CBD para el manejo de desórdenes de ansiedad en gatos(Universidad Católica de Cuenca., 2025) Molina Bernal , Brittney Lissette; Castillo Hidalgo, Edy Paul; 0107408635The research work focuses on the therapeutic management of anxiety in cats, a topic that generates a growing concern in veterinary medicine due to the high sensitivity of this species to stressors. In this context, the use of cannabidiol (CBD), a non-psychotropic component of cannabis, is explored as a possible therapeutic alternative to reduce symptoms and signs of anxiety in felines. According to a study conducted by (Mentzel et al., 2022), the following prevalence of anxiety disorders has been observed in cats: generalized anxiety disorder (15%), which is characterized by unjustified anxiety; disocialization (23%), which is defined as the absence of social behavior; deterritorialization (14%), which is shown as an alteration of territorial behavior; phobia (1.4%), understood as excessive fear; compulsive disorder (4%), which manifests itself in stereotyped behaviors; dissociative disorder (2%), which includes self-harm; and intermittent explosive aggression (3%), characterized by the presentation of unpredictable aggression. The aim of the present research was to evaluate the efficacy and safety of administering different doses of cannabidiol (CBD) compared to a control group, to determine its effects in cats clinically diagnosed with anxiety disorders. To meet this objective, nine domestic cats (Felis catus) with a clinical diagnosis of anxiety were selected. An experimental design of staggered doses was applied: 0.5 mg/kg and 1.0 mg/kg of CBD, plus a control group that received a placebo (0.9% saline). The observations were carried out for four weeks in rooms equipped to minimize external variables and to be able to objectively record the behavioral parameters that make up the FAS (Fear, anxiety, and stress) scale. Cats receiving 0.5 mg/kg showed a significant reduction in signs and symptoms of anxiety with a low incidence of side effects. In contrast, patients who received a dose of 1.0 mg/kg presented variable responses with a slight increase in side reactions. Compared to the control group, the treated animals showed greater emotional stability, reflecting the potential usefulness of CBD as an alternative treatment for anxiety disorders. Therefore, CBD, and in particular its administration orally at doses of 0.5 mg/kg, is a safe and effective option to reduce the signs of anxiety in felines. However, it is recommended to expand the research with a larger number of patients and longer follow-up periods to confirm these findings and promote their use in clinical practice. Keywords: CBD; cats; anxiety; cannabidiol; FAS scaleÍtem Acceso Abierto Efecto analgésico perioperatorio de la combinación de bupivacina al 0.5% y fentanilo por vía epidural lumbosacra en perras sometidas en ovario-histerectomía(Universidad Católica de Cuenca., 2025) Bastidas Cárdenas , Jorge Andrés; Castillo Hidalgo, Edy Paul; 0150533602Ovariohysterectomy (OVH) is a common surgical procedure in female canines, associated with intense pain due to the tissue trauma sustained during the operation. Consequently, it is essential to employ effective methodologies for preoperative analgesia. In these cases, epidural anesthesia has been recognized as a fundamental approach to alleviate postoperative discomfort due to its advantages. Therefore, the objective of this research was to evaluate the perioperative analgesic efficacy of a combination of 0.5% bupivacaine and fentanyl (50 mcg/ml), administered via the lumbosacral epidural technique, in canines undergoing ovariohysterectomy. For this purpose, apparently healthy patients aged between 1 and 5 years were selected and classified as ASA I according to the criteria established by the American Society of Anesthesiologists. The subjects were randomly distributed into two groups: the B+F group (n = 5) received a lumbosacral epidural administration of 0.5% bupivacaine combined with fentanyl (50 mcg/ml), and the B group (n = 5) was treated with 0.5% bupivacaine alone using the same route. The results showed statistically significant differences (p<0.05), where the B+F group treatment demonstrated a lower average score on the Glasgow pain scale (1.27 ± 0.87) compared to the B group (2.73 ± 0.87). These findings suggest that the combination of bupivacaine and fentanyl not only improves pain control but also may reduce the need for additional doses of anesthetics and analgesics (such as NSAIDs) during the postoperative period. Keywords: Pain relief; Canine; Ovariohysterectomy; Glasgow Pain Scale.
