Examinando por Autor "Romero Sánchez, Alexander Francisco"
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- ÍtemSolo MetadatosSíndrome mielodisplásico por deleción del brazo largo del cromosoma 5. Reporte de caso y revisión de la literatura(Universidad Católica de Cuenca., 2023) Romero Sánchez, Alexander Francisco; Reibán Espinosa, Esteban Adrián; 0703956789Myelodysplastic syndrome constitutes a group of clonal hematological entities characterized by marked cytopenias and thrombocytopenia. Only 20% of them present cytogenetic abnormalities such as deletion of the long arm of chromosome 5. For its diagnosis, peripheral blood smears are performed, evidencing dysplastic changes, biopsy of bone marrow in which he found a hypercellular marrow with dysplasia of the red series and megakaryocytes and a cytogenetic study. Treatment is based on transfusion support when necessary and lenalidomide at 10 mg/kg per day, improving symptoms. A clinical case of a 90-year-old female patient with the presence of B symptoms, long-standing anemia, leukopenia, and thrombocytopenia is presented. With anamnesis and complementary tests, myelodysplastic syndrome is diagnosed due to 5q deletion. Treatment with lenalidomide was given with a positive evolution. The objective of this case report is to determine the main clinical manifestations, diagnosis and treatment, improving the understanding of this disease.