Examinando por Autor "Parra Mejia, Marcia Tatiana"
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- ÍtemSolo MetadatosEvaluación de dureza, friabilidad, disgregación y disolución en comprimidos de paracetamol de 500 mg(Universidad Católica de Cuenca., 2023) Guachun Rocano, Yadira Micaela; Parra Mejia, Marcia Tatiana; Andrade Campoverde, Diego Paul; 0105898068; 0105270078Paracetamol is one of the most widely used drugs due to its analgesic and antipyretic activity. In its manufacture, it undergoes several quality controls, such as the determination of hardness, friability, dissolution, and disintegration. Objective. To evaluate the hardness, friability, disintegration, and dissolution in tablets containing paracetamol 500 mg in their generic and brand presentation. Methodology. The research had a quantitative approach; drug quality analyses were performed on Biobase equipme nt, model Tablet Four-usage-Tester, using quality tests based on the Brazilian Pharmacopoeia. Results. In brand and generic presentations, 882 paracetamol tablets of 500 mg from 7 different pharmaceutical laboratories were used. The hardness presented a mean of 5.9144 kgf/cm (SD=0.0000) in all manufacturing laboratories and presentations. In friability, initial and final weights varied among some laboratories; disintegration time was the same among all manufacturing laboratories and presentations. Dissolution was different among some laboratories but the same among the other displays. Conclusions. All parameters analyzed were within the average values established by the Brazilian Pharmacopoeia.