Examinando por Autor "Ortiz Amoroso , Angela Sofia"
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Ítem Acceso Abierto Influencia de los fármacos agonistas GLP-1 sobre el tejido adiposo blanco(Universidad Católica de Cuenca., 2025) Ortiz Amoroso , Angela Sofia; Barros Peláez , Ana Gabriela; 0302797725Introduction and Objective: Obesity is a chronic condition that affects the health of a significant number of the global population, which is why it currently represents a public health problem. In this context, GLP-1 agonist drugs have been developed as a promising alternative therapeutic for the treatment of obesity. These drugs act on white adipose tissue, which has generated significant interest in the scientific community. This research aims to explore the effects of GLP-1 agonist drugs on white adipose tissue and to detail their benefits in the treatment of obesity. Materials and Methods: A literature review of scientific papers published in databases such as Scopus and PubMed was conducted. Keywords based on DeCS/MeSH, such as obesity, overweight, and Glucagon-like peptide-1 (GLP-1) receptor, along with their Spanish equivalents, were used. The inclusion criteria focused on open-access articles published within the last 6 years, in Spanish and English and corresponding to meta-analyses, literature reviews, systematic reviews, and original articles. Finally, 41 high-quality articles were selected and used in this study. Conclusions: GLP-1 agonist drugs administered subcutaneously, such as semaglutide, have shown to be a promising treatment to combat overweight and obesity, not only for their weight-reduction effects, but also for maintaining glycemic control, reducing cardiac risk, generating postprandial satiety, and reducing appetite. Further studies are definitely needed to strengthen the evidence on the efficacy of this new therapeutic approach, particularly focused on the Ecuadorian population.
